DegronMD

Uniprot ID: Q9H201

Source protein: Epsin-3

Source gene: EPN3

Class: DEG_SCF_FBW7_1

Location: 363:368

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 59.4167

COIL: 0.8542

CONS_SCORE: 0.2421

DSS_SCORE: 0.5248

HELIX: 0.0948

FCONS_SCORE: 1.019

RIG_SCORE: 0.701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W361R	TCGA-AX-A0J0	UCEC	TCGA	LTPMLS	DEG_SCF_FBW7_1	0.2778
p.W361R	DO41133	UCEC	ICGC	LTPMLS	DEG_SCF_FBW7_1	0.2778
p.S370A	TCGA-BR-A4QL	STAD	TCGA	LTPMLS	DEG_SCF_FBW7_1	0.2778
p.S370A	DO38723	STAD	ICGC	LTPMLS	DEG_SCF_FBW7_1	0.2778
p.W361C	TCGA-EE-A183	SKCM	TCGA	LTPMLS	DEG_SCF_FBW7_1	0.2778
p.W361C	DO37715	SKCM	ICGC	LTPMLS	DEG_SCF_FBW7_1	0.2778
p.V354I	TCGA-EX-A3L1	CESC	TCGA	LTPMLS	DEG_SCF_FBW7_1	0.0833
p.V354I	TCGA-VQ-A91D	STAD	TCGA	LTPMLS	DEG_SCF_FBW7_1	0.0833
p.V354I	DO6335	CESC	ICGC	LTPMLS	DEG_SCF_FBW7_1	0.0833
p.V354I	DO51783	STAD	ICGC	LTPMLS	DEG_SCF_FBW7_1	0.0833
p.V354I	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPMLS	DEG_SCF_FBW7_1	0.0833
p.V354I	ACH-002272	Lymphoma	CCLE	LTPMLS	DEG_SCF_FBW7_1	0.0833
p.V354I	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPMLS	DEG_SCF_FBW7_1	0.0833
p.R357Q	TCGA-EY-A1GI	UCEC	TCGA	LTPMLS	DEG_SCF_FBW7_1	0.1667
p.R357Q	DO41211	UCEC	ICGC	LTPMLS	DEG_SCF_FBW7_1	0.1667
p.T376N	TCGA-WE-A8ZN	SKCM	TCGA	LTPMLS	DEG_SCF_FBW7_1	0.1111
p.T376N	DO51285	SKCM	ICGC	LTPMLS	DEG_SCF_FBW7_1	0.1111
p.P360L	DO228190	LICA	ICGC	LTPMLS	DEG_SCF_FBW7_1	0.25
p.R357G	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LTPMLS	DEG_SCF_FBW7_1	0.1667
p.R357G	SIDM00529	Breast Carcinoma	GDSC	LTPMLS	DEG_SCF_FBW7_1	0.1667
p.R357G	SIDM00493	Other Solid Cancers	GDSC	LTPMLS	DEG_SCF_FBW7_1	0.1667
p.R357G	SIDM01525	Acute Myeloid Leukemia	GDSC	LTPMLS	DEG_SCF_FBW7_1	0.1667
p.L367F	SIDM01612	Endometrial Carcinoma	GDSC	LTPMLS	DEG_SCF_FBW7_1	0.587
p.L367F	ACH-000946	Endometrial/Uterine Cancer	CCLE	LTPMLS	DEG_SCF_FBW7_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H201	Epsin-3	DEG_SCF_FBW7_1	363:368	LTPMLS	FBXW7	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons