DegronMD

Uniprot ID: O60437

Source protein: Periplakin

Source gene: PPL

Class: DEG_APCC_DBOX_1

Location: 504:512

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.535

ASA_SCORE: 77.0667

COIL: 0.191

CONS_SCORE: 0.4794

DSS_SCORE: 0.4073

HELIX: 0.8073

FCONS_SCORE: 1.1298

RIG_SCORE: 0.7631

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D501N	TCGA-CG-5726	STAD	TCGA	GRQLLAGLD	DEG_APCC_DBOX_1	0.25
p.G504E	TCGA-D1-A167	UCEC	TCGA	GRQLLAGLD	DEG_APCC_DBOX_1	0.6087
p.D519N	TCGA-D3-A3MU	SKCM	TCGA	GRQLLAGLD	DEG_APCC_DBOX_1	0.1389
p.R505W	TCGA-E6-A1LX	UCEC	TCGA	GRQLLAGLD	DEG_APCC_DBOX_1	0.8634
p.R505W	TCGA-G4-6299	COAD	TCGA	GRQLLAGLD	DEG_APCC_DBOX_1	0.8634
p.R505W	SIDM02039	Colorectal Carcinoma	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	0.8634
p.R503W	DO7874	COAD	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	0.3056
p.R503W	DO41020	UCEC	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	0.3056
p.K511R	DO234182	ESAD	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	0.7237
p.D517N	DO47337	SKCM	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	0.1944
p.D499N	DO38483	STAD	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	0.1944
p.L506P	DO229211	THCA	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	0.7582
p.G502E	DO40978	UCEC	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	0.2778
p.G497R	SIDM00334	Endometrial Carcinoma	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	0.1389
p.G497R	ACH-000773	Lymphoma	CCLE	GRQLLAGLD	DEG_APCC_DBOX_1	0.1389
p.G497R	ACH-000879	Endometrial/Uterine Cancer	CCLE	GRQLLAGLD	DEG_APCC_DBOX_1	0.1389
p.G497R	MFE-296	endometrium	COSMIC	GRQLLAGLD	DEG_APCC_DBOX_1	0.1389
p.R520Q	SIDM00087	Plasma Cell Myeloma	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	0.1111
p.R520Q	SIDM01681	Non-Cancerous	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	0.1111
p.A509T	SIDM01609	Endometrial Carcinoma	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	0.6028
p.A509T	ACH-000972	Endometrial/Uterine Cancer	CCLE	GRQLLAGLD	DEG_APCC_DBOX_1	0.6028
p.E494K	SIDM01629	Melanoma	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	0.0556
p.E494K	ACH-000404	Skin Cancer	CCLE	GRQLLAGLD	DEG_APCC_DBOX_1	0.0556
p.G495R	MFE-296	endometrium	COSMIC	GRQLLAGLD	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60437	Periplakin	DEG_APCC_DBOX_1	504:512	GRQLLAGLD	APC,CDC20,FZR1	0.535	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRQLLAGLD

Degron related mutations and impact score

Drug responses associated with PPL mutations

All proteins holding degron of GRQLLAGLD