DegronMD - O60437(PPL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1670Y	TCGA-4W-AA9S	GBM	TCGA	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation blocking phosphorylation signal	0.6111
p.R1650Q	TCGA-5M-AAT6	COAD	TCGA	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.0833
p.R1650Q	TCGA-AM-5821	COAD	TCGA	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.0833
p.L1654M	TCGA-AP-A1DK	UCEC	TCGA	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.1944
p.T847A	TCGA-AX-A2HD	UCEC	TCGA	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.1667
p.R1656C	TCGA-BR-4292	STAD	TCGA	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.25
p.R1656C	TCGA-BR-4361	STAD	TCGA	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.25
p.D501N	TCGA-CG-5726	STAD	TCGA	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.25
p.Q855H	TCGA-CN-A6V1	HNSC	TCGA	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation altering degron motif	0.647
p.G504E	TCGA-D1-A167	UCEC	TCGA	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.6087
p.D519N	TCGA-D3-A3MU	SKCM	TCGA	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1389
p.Y850F	TCGA-DD-AACU	LIHC	TCGA	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation blocking phosphorylation signal	0.6944
p.R505W	TCGA-E6-A1LX	UCEC	TCGA	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.8634
p.R505W	TCGA-G4-6299	COAD	TCGA	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.8634
p.R505W	SIDM02039	Colorectal Carcinoma	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.8634
p.I852M	TCGA-JW-A5VJ	CESC	TCGA	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.3056
p.I850M	DO49974	CESC	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation blocking phosphorylation signal	0.6944
p.R503W	DO7874	COAD	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.3056
p.R503W	DO41020	UCEC	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.3056
p.K511R	DO234182	ESAD	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.7237
p.S1668Y	DO219108	GBM	ICGC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.2222
p.Q853H	DO52048	HNSC	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation altering degron motif	0.7582
p.D1662E	DO229028	LICA	ICGC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation altering degron motif	0.6758
p.L855M	DO229034	LICA	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation altering degron motif	0.711
p.Y848F	DO52213	LIHC	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.1944
p.R1653W	DO232224	PBCA	ICGC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.1667
p.R1653W	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.1667
p.D517N	DO47337	SKCM	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1944
p.R1654C	DO38887	STAD	ICGC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.1944
p.R1654C	DO38495	STAD	ICGC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.1944
p.D499N	DO38483	STAD	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1944
p.L506P	DO229211	THCA	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.7582
p.R1674H	DO40996	UCEC	ICGC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.0556
p.R1674H	NCI-H1975	lung	COSMIC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.0556
p.G502E	DO40978	UCEC	ICGC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.2778
p.L1652M	DO42033	UCEC	ICGC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.1389
p.E870K	DO41791	UCEC	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.0833
p.T845A	DO42608	UCEC	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation substituting flanking lysine	0.2222
p.G497R	SIDM00334	Endometrial Carcinoma	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1389
p.G497R	ACH-000773	Lymphoma	CCLE	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1389
p.G497R	ACH-000879	Endometrial/Uterine Cancer	CCLE	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1389
p.G497R	MFE-296	endometrium	COSMIC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1389
p.P871L	SIDM01137	Pancreatic Carcinoma	GDSC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.0556
p.P871L	ACH-000235	Pancreatic Cancer	CCLE	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.0556
p.P871L	PANC-04-03	pancreas	COSMIC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.0556
p.R854T	SIDM00643	Non-Cancerous	GDSC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation altering degron motif	0.7876
p.R520Q	SIDM00087	Plasma Cell Myeloma	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1111
p.R520Q	SIDM01681	Non-Cancerous	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1111
p.A844T	SIDM00447	B-Lymphoblastic Leukemia	GDSC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.0833
p.A844T	ACH-000960	Leukemia	CCLE	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.0833
p.A844T	REH	haematopoietic and lymphoid tissue	COSMIC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.0833
p.R1655W	SIDM00121	T-Lymphoblastic Leukemia	GDSC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.2222
p.R1655W	ACH-001738	Leukemia	CCLE	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.2222
p.R1655W	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.2222
p.A509T	SIDM01609	Endometrial Carcinoma	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.6028
p.A509T	ACH-000972	Endometrial/Uterine Cancer	CCLE	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.6028
p.E494K	SIDM01629	Melanoma	GDSC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.0556
p.E494K	ACH-000404	Skin Cancer	CCLE	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.0556
p.G495R	MFE-296	endometrium	COSMIC	GRQLLAGLD	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.0833
p.R1674C	SW48	large intestine	COSMIC	VVIHPD	LIG_APCC_ABBA_1	1659:1664	Mutation rewiring degron network	0.0556
p.P869L	PANC-04-03	pancreas	COSMIC	NRQRLQNLE	DEG_APCC_DBOX_1	853:861	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPL

UniProt ID: O60437

Entrez ID: 5493

Protein name: Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPL in