DegronMD

Uniprot ID: O60437

Source protein: Periplakin

Source gene: PPL

Class: LIG_APCC_ABBA_1

Location: 1659:1664

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9386

ASA_SCORE: 81.9833

COIL: 0.5753

CONS_SCORE: 0.7094

DSS_SCORE: 0.3953

HELIX: 0.0605

FCONS_SCORE: 1.0108

RIG_SCORE: 0.7703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1670Y	TCGA-4W-AA9S	GBM	TCGA	VVIHPD	LIG_APCC_ABBA_1	0.6111
p.R1650Q	TCGA-5M-AAT6	COAD	TCGA	VVIHPD	LIG_APCC_ABBA_1	0.0833
p.R1650Q	TCGA-AM-5821	COAD	TCGA	VVIHPD	LIG_APCC_ABBA_1	0.0833
p.L1654M	TCGA-AP-A1DK	UCEC	TCGA	VVIHPD	LIG_APCC_ABBA_1	0.1944
p.R1656C	TCGA-BR-4292	STAD	TCGA	VVIHPD	LIG_APCC_ABBA_1	0.25
p.R1656C	TCGA-BR-4361	STAD	TCGA	VVIHPD	LIG_APCC_ABBA_1	0.25
p.S1668Y	DO219108	GBM	ICGC	VVIHPD	LIG_APCC_ABBA_1	0.2222
p.D1662E	DO229028	LICA	ICGC	VVIHPD	LIG_APCC_ABBA_1	0.6758
p.R1653W	DO232224	PBCA	ICGC	VVIHPD	LIG_APCC_ABBA_1	0.1667
p.R1653W	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	VVIHPD	LIG_APCC_ABBA_1	0.1667
p.R1654C	DO38887	STAD	ICGC	VVIHPD	LIG_APCC_ABBA_1	0.1944
p.R1654C	DO38495	STAD	ICGC	VVIHPD	LIG_APCC_ABBA_1	0.1944
p.R1674H	DO40996	UCEC	ICGC	VVIHPD	LIG_APCC_ABBA_1	0.0556
p.R1674H	NCI-H1975	lung	COSMIC	VVIHPD	LIG_APCC_ABBA_1	0.0556
p.L1652M	DO42033	UCEC	ICGC	VVIHPD	LIG_APCC_ABBA_1	0.1389
p.R1655W	SIDM00121	T-Lymphoblastic Leukemia	GDSC	VVIHPD	LIG_APCC_ABBA_1	0.2222
p.R1655W	ACH-001738	Leukemia	CCLE	VVIHPD	LIG_APCC_ABBA_1	0.2222
p.R1655W	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	VVIHPD	LIG_APCC_ABBA_1	0.2222
p.R1674C	SW48	large_intestine	COSMIC	VVIHPD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60437	Periplakin	LIG_APCC_ABBA_1	1659:1664	VVIHPD	APC,CDC20,FZR1	0.9386	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons