DegronMD

Uniprot ID: O60437

Source protein: Periplakin

Source gene: PPL

Class: DEG_APCC_DBOX_1

Location: 853:861

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7302

ASA_SCORE: 82.6889

COIL: 0.0487

CONS_SCORE: 0.7013

DSS_SCORE: 0.0996

HELIX: 0.9521

FCONS_SCORE: 1.3084

RIG_SCORE: 0.8636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T847A	TCGA-AX-A2HD	UCEC	TCGA	NRQRLQNLE	DEG_APCC_DBOX_1	0.1667
p.Q855H	TCGA-CN-A6V1	HNSC	TCGA	NRQRLQNLE	DEG_APCC_DBOX_1	0.647
p.Y850F	TCGA-DD-AACU	LIHC	TCGA	NRQRLQNLE	DEG_APCC_DBOX_1	0.6944
p.I852M	TCGA-JW-A5VJ	CESC	TCGA	NRQRLQNLE	DEG_APCC_DBOX_1	0.3056
p.I850M	DO49974	CESC	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	0.6944
p.Q853H	DO52048	HNSC	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	0.7582
p.L855M	DO229034	LICA	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	0.711
p.Y848F	DO52213	LIHC	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	0.1944
p.E870K	DO41791	UCEC	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	0.0833
p.T845A	DO42608	UCEC	ICGC	NRQRLQNLE	DEG_APCC_DBOX_1	0.2222
p.P871L	SIDM01137	Pancreatic Carcinoma	GDSC	NRQRLQNLE	DEG_APCC_DBOX_1	0.0556
p.P871L	ACH-000235	Pancreatic Cancer	CCLE	NRQRLQNLE	DEG_APCC_DBOX_1	0.0556
p.P871L	PANC-04-03	pancreas	COSMIC	NRQRLQNLE	DEG_APCC_DBOX_1	0.0556
p.R854T	SIDM00643	Non-Cancerous	GDSC	NRQRLQNLE	DEG_APCC_DBOX_1	0.7876
p.A844T	SIDM00447	B-Lymphoblastic Leukemia	GDSC	NRQRLQNLE	DEG_APCC_DBOX_1	0.0833
p.A844T	ACH-000960	Leukemia	CCLE	NRQRLQNLE	DEG_APCC_DBOX_1	0.0833
p.A844T	REH	haematopoietic_and_lymphoid_tissue	COSMIC	NRQRLQNLE	DEG_APCC_DBOX_1	0.0833
p.P869L	PANC-04-03	pancreas	COSMIC	NRQRLQNLE	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60437	Periplakin	DEG_APCC_DBOX_1	853:861	NRQRLQNLE	APC,CDC20,FZR1	0.7302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons