DegronMD

Uniprot ID: Q96AQ8

Source protein: Mitochondrial calcium uniporter regulator 1

Source gene: MCUR1

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6675

ASA_SCORE: 85.4111

COIL: 0.6701

CONS_SCORE: 0.6623

DSS_SCORE: 0.4612

HELIX: 0.2272

FCONS_SCORE: 1.0267

RIG_SCORE: 0.8114

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R13H	DO229268	THCA	ICGC	GRQRLLFLP	DEG_APCC_DBOX_1	0.25
p.P31R	SIDM00773	Non-Cancerous	GDSC	GRQRLLFLP	DEG_APCC_DBOX_1	0.1389
p.P31R	ACH-000691	Breast Cancer	CCLE	GRQRLLFLP	DEG_APCC_DBOX_1	0.1389
p.G32A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	GRQRLLFLP	DEG_APCC_DBOX_1	0.1111
p.G32A	ACH-001669	Leukemia	CCLE	GRQRLLFLP	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AQ8	Mitochondrial calcium uniporter regulator 1	DEG_APCC_DBOX_1	16:24	GRQRLLFLP	APC,CDC20,FZR1	0.6675	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons