DegronMD

Uniprot ID: Q9NTU7

Source protein: Cerebellin-4

Source gene: CBLN4

Class: DEG_APCC_DBOX_1

Location: 4:12

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8843

ASA_SCORE: 77.8667

COIL: 0.8152

CONS_SCORE: 0.3149

DSS_SCORE: 0.2628

HELIX: 0.1129

FCONS_SCORE: 0.8221

RIG_SCORE: 0.7691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R5C	DO234416	ESAD	ICGC	GRRALSAVP	DEG_APCC_DBOX_1	0.8301
p.R6G	DO229242	THCA	ICGC	GRRALSAVP	DEG_APCC_DBOX_1	0.6457
p.G4A	SIDM00845	Burkitt's Lymphoma	GDSC	GRRALSAVP	DEG_APCC_DBOX_1	0.6429
p.R5H	SIDM01113	Other Sarcomas	GDSC	GRRALSAVP	DEG_APCC_DBOX_1	0.8244
p.R5H	ACH-000939	Sarcoma	CCLE	GRRALSAVP	DEG_APCC_DBOX_1	0.8244
p.A13T	SIDM01662	Plasma Cell Myeloma	GDSC	GRRALSAVP	DEG_APCC_DBOX_1	0.3056
p.A10V	SIDM01424	B-Lymphoblastic Leukemia	GDSC	GRRALSAVP	DEG_APCC_DBOX_1	0.5825
p.A10V	ACH-001735	Leukemia	CCLE	GRRALSAVP	DEG_APCC_DBOX_1	0.5825
p.A7E	ACH-000616	Gastric Cancer	CCLE	GRRALSAVP	DEG_APCC_DBOX_1	0.659

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NTU7	Cerebellin-4	DEG_APCC_DBOX_1	4:12	GRRALSAVP	APC,CDC20,FZR1	0.8843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons