DegronMD

Uniprot ID: O43424

Source protein: Glutamate receptor ionotropic, delta-2

Source gene: GRID2

Class: DEG_APCC_DBOX_1

Location: 366:374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8028

ASA_SCORE: 49.8111

COIL: 0.1391

CONS_SCORE: 0.4649

DSS_SCORE: 0.4875

HELIX: 0.8503

FCONS_SCORE: 1.2064

RIG_SCORE: 0.7513

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E384K	TCGA-18-4083	LUSC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.0556
p.E384K	DO26504	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.0556
p.Q364H	TCGA-22-5474	LUSC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.2778
p.L381F	TCGA-55-A490	LUAD	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.1389
p.L381F	DO24596	LUAD	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.1389
p.G365C	TCGA-77-8138	LUSC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.3056
p.G365C	DO233079	GACA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.3056
p.G365C	DO26510	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.3056
p.P362S	TCGA-A5-A0G1	UCEC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.2222
p.P362S	TCGA-BS-A0T9	UCEC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.2222
p.P362S	DO41026	UCEC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.2222
p.P362S	DO42472	UCEC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.2222
p.R367C	TCGA-AX-A1CE	UCEC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.8301
p.R367C	TCGA-FI-A2D5	UCEC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.8301
p.R367C	SIDM01311	Esophageal Carcinoma	GDSC	GRSMLETIK	DEG_APCC_DBOX_1	0.8301
p.S368F	TCGA-EE-A29D	SKCM	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.6871
p.K374N	TCGA-EI-6917	READ	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.5806
p.I356M	TCGA-IR-A3LL	CESC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.0556
p.I356M	DO44362	CESC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.0556
p.I356M	DO218306	ORCA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.0556
p.M369T	TCGA-NH-A6GB	COAD	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.6312
p.M369T	DO50092	COAD	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.6312
p.R367H	TCGA-W3-A828	SKCM	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	0.8244
p.R367H	DO233272	GACA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.8244
p.R367H	DO51273	SKCM	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.8244
p.N359T	DO234234	ESAD	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.1389
p.P369L	DO223082	ESCA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.7582
p.P357T	DO222437	ESCA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.0833
p.V378F	DO229045	LICA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.2222
p.G374D	DO45229	LIRI	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.7198
p.D381N	DO23554	LUAD	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.1389
p.V379I	DO26463	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.1944
p.V379F	DO26479	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.1944
p.G374R	DO26617	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.7568
p.S384T	DO222710	MELA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.0556
p.E356K	DO27879	ORCA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.0556
p.G367C	DO37523	SKCM	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	0.76
p.K361E	ACH-001061	Colon/Colorectal Cancer	CCLE	GRSMLETIK	DEG_APCC_DBOX_1	0.3056
p.S376F	BHT-101	thyroid	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	0.2778
p.R358S	LCLC-97TM1	lung	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	0.2222
p.R358G	NCI-H446	lung	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	0.2222
p.L368P	NCI-H2172	lung	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	0.7582
p.S362F	BHT-101	thyroid	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRSMLETIK

Degron related mutations and impact score

Drug responses associated with GRID2 mutations

All proteins holding degron of GRSMLETIK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43424	Glutamate receptor ionotropic, delta-2	DEG_APCC_DBOX_1	366:374	GRSMLETIK	APC,CDC20,FZR1	0.8028	More...