DegronMD - O43424(GRID2)

FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511). {ECO:0000269|PubMed:27418511}.

GO - Biological processes (BP): cellular protein localization [GO:0034613]; cerebellar granule cell differentiation [GO:0021707]; excitatory postsynaptic potential [GO:0060079]; excitatory synapse assembly [GO:1904861]; glutamate receptor signaling pathway [GO:0007215]; heterophilic cell-cell adhesion via plasma membrane cell adhe... View more >>

GO - Molecular function (MF): glutamate receptor activity [GO:0008066]; ionotropic glutamate receptor activity [GO:0004970]; ligand-gated ion channel activity [GO:0015276]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; transmitter-gated ion channel activity invo... View more >>

GO - Cellular component (CC): dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; integral component of plasma membrane [GO:0005887]; integral component of postsynaptic density membrane [GO:0099061]; ionotropic glutamate receptor complex [GO:0008328]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma mem... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R367C	TCGA-AX-A1CE	UCEC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.R367C	TCGA-FI-A2D5	UCEC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.R367C	SIDM01311	Esophageal Carcinoma	GDSC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.R367H	TCGA-W3-A828	SKCM	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8244
p.R367H	DO233272	GACA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8244
p.R367H	DO51273	SKCM	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8244
p.G367C	DO37523	SKCM	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.76
p.P369L	DO223082	ESCA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7582
p.L368P	NCI-H2172	lung	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7582
p.G374R	DO26617	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7568
p.R913Q	SIDM00254	Neuroblastoma	GDSC	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7329
p.R913Q	ACH-002283	Neuroblastoma	CCLE	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7329
p.R913Q	NB5	autonomic ganglia	COSMIC	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7329
p.T912K	TCGA-49-AAR4	LUAD	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7306
p.G374D	DO45229	LIRI	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7198
p.S368F	TCGA-EE-A29D	SKCM	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.6871
p.M369T	TCGA-NH-A6GB	COAD	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.6312
p.M369T	DO50092	COAD	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.6312
p.K374N	TCGA-EI-6917	READ	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.5806
p.G903C	DO229035	LICA	ICGC	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation blocking phosphorylation signal	0.5278

Showing 1 to 20 of 55 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRID2

UniProt ID: O43424

Entrez ID: 2895

Protein name: Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRID2 in