DegronMD - O43424(GRID2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E384K	TCGA-18-4083	LUSC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.E384K	DO26504	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.Q364H	TCGA-22-5474	LUSC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2778
p.T912K	TCGA-49-AAR4	LUAD	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7306
p.L905V	TCGA-55-A48X	LUAD	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1389
p.L381F	TCGA-55-A490	LUAD	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.L381F	DO24596	LUAD	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.G365C	TCGA-77-8138	LUSC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.3056
p.G365C	DO233079	GACA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.3056
p.G365C	DO26510	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.3056
p.P362S	TCGA-A5-A0G1	UCEC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2222
p.P362S	TCGA-BS-A0T9	UCEC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2222
p.P362S	DO41026	UCEC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2222
p.P362S	DO42472	UCEC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2222
p.P911S	TCGA-AA-3984	COAD	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.3056
p.R367C	TCGA-AX-A1CE	UCEC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.R367C	TCGA-FI-A2D5	UCEC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.R367C	SIDM01311	Esophageal Carcinoma	GDSC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.T930S	TCGA-BP-5186	KIRC	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.0556
p.P904A	TCGA-CR-7371	HNSC	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1111
p.P904L	TCGA-D3-A51G	SKCM	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1111
p.T925I	TCGA-DU-6392	LGG	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1944
p.S368F	TCGA-EE-A29D	SKCM	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.6871
p.K374N	TCGA-EI-6917	READ	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.5806
p.I356M	TCGA-IR-A3LL	CESC	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.I356M	DO44362	CESC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.I356M	DO218306	ORCA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.H926N	TCGA-MN-A4N4	LUAD	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.M369T	TCGA-NH-A6GB	COAD	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.6312
p.M369T	DO50092	COAD	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.6312
p.R367H	TCGA-W3-A828	SKCM	TCGA	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8244
p.R367H	DO233272	GACA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8244
p.R367H	DO51273	SKCM	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8244
p.N359T	DO234234	ESAD	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.P369L	DO223082	ESCA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7582
p.P357T	DO222437	ESCA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0833
p.G903C	DO229035	LICA	ICGC	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation blocking phosphorylation signal	0.5278
p.V378F	DO229045	LICA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2222
p.G374D	DO45229	LIRI	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7198
p.D381N	DO23554	LUAD	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1389
p.V379I	DO26463	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1944
p.V379F	DO26479	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1944
p.G374R	DO26617	LUSC	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7568
p.S384T	DO222710	MELA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.E356K	DO27879	ORCA	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.G367C	DO37523	SKCM	ICGC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.76
p.R913Q	SIDM00254	Neuroblastoma	GDSC	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7329
p.R913Q	ACH-002283	Neuroblastoma	CCLE	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7329
p.R913Q	NB5	autonomic ganglia	COSMIC	TRQALEQIS	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.7329
p.K361E	ACH-001061	Colon/Colorectal Cancer	CCLE	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation substituting flanking lysine	0.3056
p.S376F	BHT-101	thyroid	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2778
p.R358S	LCLC-97TM1	lung	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation substituting flanking lysine	0.2222
p.R358G	NCI-H446	lung	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation substituting flanking lysine	0.2222
p.L368P	NCI-H2172	lung	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7582
p.S362F	BHT-101	thyroid	COSMIC	GRSMLETIK	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2222

Kaplan plot for GRID2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRID2

UniProt ID: O43424

Entrez ID: 2895

Protein name: Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRID2 in