DegronMD

Uniprot ID: O43424

Source protein: Glutamate receptor ionotropic, delta-2

Source gene: GRID2

Class: DEG_APCC_DBOX_1

Location: 912:920

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5178

ASA_SCORE: 83.1444

COIL: 0.572

CONS_SCORE: 0.248

DSS_SCORE: 0.38

HELIX: 0.369

FCONS_SCORE: 0.9394

RIG_SCORE: 0.7997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T912K	TCGA-49-AAR4	LUAD	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	0.7306
p.L905V	TCGA-55-A48X	LUAD	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	0.1389
p.P911S	TCGA-AA-3984	COAD	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	0.3056
p.T930S	TCGA-BP-5186	KIRC	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	0.0556
p.P904A	TCGA-CR-7371	HNSC	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	0.1111
p.P904L	TCGA-D3-A51G	SKCM	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	0.1111
p.T925I	TCGA-DU-6392	LGG	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	0.1944
p.H926N	TCGA-MN-A4N4	LUAD	TCGA	TRQALEQIS	DEG_APCC_DBOX_1	0.1667
p.G903C	DO229035	LICA	ICGC	TRQALEQIS	DEG_APCC_DBOX_1	0.5278
p.R913Q	SIDM00254	Neuroblastoma	GDSC	TRQALEQIS	DEG_APCC_DBOX_1	0.7329
p.R913Q	ACH-002283	Neuroblastoma	CCLE	TRQALEQIS	DEG_APCC_DBOX_1	0.7329
p.R913Q	NB5	autonomic_ganglia	COSMIC	TRQALEQIS	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43424	Glutamate receptor ionotropic, delta-2	DEG_APCC_DBOX_1	912:920	TRQALEQIS	APC,CDC20,FZR1	0.5178	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons