DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_APCC_DBOX_1

Location: 1335:1343

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5082

ASA_SCORE: 90.3444

COIL: 0.87

CONS_SCORE: 0.5289

DSS_SCORE: 0.4953

HELIX: 0.0141

FCONS_SCORE: 0.8596

RIG_SCORE: 0.7263

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1326G	TCGA-23-1114	OV	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.0833
p.S1326G	DO32337	OV	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.0833
p.V1349A	TCGA-A6-5665	COAD	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.1667
p.V1349A	DO9756	COAD	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.1667
p.T1325A	TCGA-B7-5816	STAD	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.0556
p.T1325A	DO38599	STAD	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.0556
p.P1328S	TCGA-BR-7707	STAD	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.1389
p.P1328S	DO38487	STAD	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.1389
p.G1335E	TCGA-D3-A8GI	SKCM	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.6087
p.G1335E	TCGA-W3-AA1V	SKCM	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.6087
p.G1335E	DO50284	SKCM	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.6087
p.G1335E	DO51276	SKCM	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.6087
p.T1325S	TCGA-DA-A95Z	SKCM	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.0556
p.T1325S	DO219481	SKCM	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.0556
p.T1337P	TCGA-EO-A3B0	UCEC	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.5919
p.T1337P	DO219773	UCEC	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.5919
p.G1335R	TCGA-FR-A7U9	SKCM	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.6457
p.G1335R	DO48546	SKCM	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.6457
p.G1335R	SIDM01059	Melanoma	GDSC	GRTPLTSIP	DEG_APCC_DBOX_1	0.6457
p.G1335R	ACH-000915	Skin Cancer	CCLE	GRTPLTSIP	DEG_APCC_DBOX_1	0.6457
p.G1335R	IPC-298	skin	COSMIC	GRTPLTSIP	DEG_APCC_DBOX_1	0.6457
p.T1340R	TCGA-G2-A2ES	BLCA	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.6765
p.T1340R	DO785	BLCA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.6765
p.E1334K	TCGA-L5-A8NQ	ESCA	TCGA	GRTPLTSIP	DEG_APCC_DBOX_1	0.3056
p.A1353T	DO230311	COCA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.0556
p.L1348P	DO229013	COCA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.1944
p.L1348P	DO229016	COCA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.1944
p.L1348P	DO228941	LICA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.1944
p.L1348P	DO228947	LICA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.1944
p.T1331S	DO233702	GACA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.2222
p.P1343T	DO228941	LICA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.5919
p.R1336S	DO229052	LICA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.7427
p.I1342M	DO229052	LICA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.6507
p.P1338S	DO220882	MELA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.5641
p.P1338T	DO232224	PBCA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.5919
p.M1327I	DO46980	RECA	ICGC	GRTPLTSIP	DEG_APCC_DBOX_1	0.1111
p.S1341N	SIDM00660	Colorectal Carcinoma	GDSC	GRTPLTSIP	DEG_APCC_DBOX_1	0.5958
p.S1341N	SIDM00808	Burkitt's Lymphoma	GDSC	GRTPLTSIP	DEG_APCC_DBOX_1	0.5958
p.S1333T	SIDM00032	Bladder Carcinoma	GDSC	GRTPLTSIP	DEG_APCC_DBOX_1	0.2778
p.T1329S	SIDM00808	Burkitt's Lymphoma	GDSC	GRTPLTSIP	DEG_APCC_DBOX_1	0.1667
p.T1329S	SIDM01254	Burkitt's Lymphoma	GDSC	GRTPLTSIP	DEG_APCC_DBOX_1	0.1667
p.T1329S	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	GRTPLTSIP	DEG_APCC_DBOX_1	0.1667
p.I1342V	SIDM01774	Pancreatic Carcinoma	GDSC	GRTPLTSIP	DEG_APCC_DBOX_1	0.5965
p.I1342V	ACH-000205	Pancreatic Cancer	CCLE	GRTPLTSIP	DEG_APCC_DBOX_1	0.5965

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRTPLTSIP

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of GRTPLTSIP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_APCC_DBOX_1	1335:1343	GRTPLTSIP	APC,CDC20,FZR1	0.5082	More...