DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_APCC_DBOX_1

Location: 1688:1696

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9521

ASA_SCORE: 90.8333

COIL: 0.847

CONS_SCORE: 0.7327

DSS_SCORE: 0.578

HELIX: 0.0153

FCONS_SCORE: 1.3845

RIG_SCORE: 0.7473

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1696N	TCGA-05-4410	LUAD	TCGA	GRTPLTSIT	DEG_APCC_DBOX_1	0.5944
p.T1696N	DO25426	LUAD	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.5944
p.G1688R	TCGA-86-7954	LUAD	TCGA	GRTPLTSIT	DEG_APCC_DBOX_1	0.6457
p.G1688R	DO23660	LUAD	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.6457
p.I1695M	TCGA-AD-6889	COAD	TCGA	GRTPLTSIT	DEG_APCC_DBOX_1	0.6507
p.I1695M	DO8463	COAD	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.6507
p.I1695M	DO222553	COCA	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.6507
p.T1684A	TCGA-B0-5098	KIRC	TCGA	GRTPLTSIT	DEG_APCC_DBOX_1	0.2222
p.T1684A	DO18938	KIRC	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.2222
p.P1691S	TCGA-EE-A2GC	SKCM	TCGA	GRTPLTSIT	DEG_APCC_DBOX_1	0.5641
p.P1691S	TCGA-QB-AA9O	SKCM	TCGA	GRTPLTSIT	DEG_APCC_DBOX_1	0.5641
p.P1691S	DO37839	SKCM	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.5641
p.P1691S	DO51267	SKCM	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.5641
p.P1681S	TCGA-ER-A19G	SKCM	TCGA	GRTPLTSIT	DEG_APCC_DBOX_1	0.1389
p.P1681S	DO47284	SKCM	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.1389
p.G1688E	DO222553	COCA	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.6087
p.G1688E	DO52365	LUSC	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.6087
p.G1688E	DO218859	SKCA	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.6087
p.T1696P	DO222553	COCA	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.5919
p.T1686S	DO229013	COCA	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.2778
p.T1686S	DO229016	COCA	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.2778
p.T1696A	DO231072	LUSC	ICGC	GRTPLTSIT	DEG_APCC_DBOX_1	0.6028
p.L1692S	SIDM00608	Plasma Cell Myeloma	GDSC	GRTPLTSIT	DEG_APCC_DBOX_1	0.7667
p.L1692S	ACH-000714	Myeloma	CCLE	GRTPLTSIT	DEG_APCC_DBOX_1	0.7667
p.L1692S	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	GRTPLTSIT	DEG_APCC_DBOX_1	0.7667
p.S1694N	SIDM00660	Colorectal Carcinoma	GDSC	GRTPLTSIT	DEG_APCC_DBOX_1	0.5958
p.S1694N	SIDM00808	Burkitt's Lymphoma	GDSC	GRTPLTSIT	DEG_APCC_DBOX_1	0.5958
p.S1694N	SIDM01173	Rhabdomyosarcoma	GDSC	GRTPLTSIT	DEG_APCC_DBOX_1	0.5958
p.S1694N	SIDM01254	Burkitt's Lymphoma	GDSC	GRTPLTSIT	DEG_APCC_DBOX_1	0.5958
p.T1678I	SIDM01047	Chronic Myelogenous Leukemia	GDSC	GRTPLTSIT	DEG_APCC_DBOX_1	0.0556
p.T1678I	ACH-000295	Leukemia	CCLE	GRTPLTSIT	DEG_APCC_DBOX_1	0.0556
p.T1678I	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	GRTPLTSIT	DEG_APCC_DBOX_1	0.0556
p.T1682S	SIDM00808	Burkitt's Lymphoma	GDSC	GRTPLTSIT	DEG_APCC_DBOX_1	0.1667
p.T1682S	SIDM01254	Burkitt's Lymphoma	GDSC	GRTPLTSIT	DEG_APCC_DBOX_1	0.1667
p.T1682S	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	GRTPLTSIT	DEG_APCC_DBOX_1	0.1667
p.T1682I	SIDM01776	Plasma Cell Myeloma	GDSC	GRTPLTSIT	DEG_APCC_DBOX_1	0.1667
p.T1682I	ACH-001162	Myeloma	CCLE	GRTPLTSIT	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRTPLTSIT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of GRTPLTSIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_APCC_DBOX_1	1688:1696	GRTPLTSIT	APC,CDC20,FZR1	0.9521	More...