DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_APCC_DBOX_1

Location: 863:871

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7787

ASA_SCORE: 96.1333

COIL: 0.9117

CONS_SCORE: 0.5236

DSS_SCORE: 0.5654

HELIX: 0.0148

FCONS_SCORE: 0.897

RIG_SCORE: 0.6932

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T853N	TCGA-22-4613	LUSC	TCGA	GRTPLTSMP	DEG_APCC_DBOX_1	0.0556
p.T853N	DO26468	LUSC	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.0556
p.A878T	TCGA-B5-A0K6	UCEC	TCGA	GRTPLTSMP	DEG_APCC_DBOX_1	0.1389
p.A878T	DO40808	UCEC	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.1389
p.T874I	TCGA-B5-A11E	UCEC	TCGA	GRTPLTSMP	DEG_APCC_DBOX_1	0.25
p.T874I	DO41644	UCEC	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.25
p.S854N	TCGA-B6-A40C	BRCA	TCGA	GRTPLTSMP	DEG_APCC_DBOX_1	0.0833
p.S854N	DO50045	BRCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.0833
p.S880Y	TCGA-DK-A2I1	BLCA	TCGA	GRTPLTSMP	DEG_APCC_DBOX_1	0.0833
p.S880Y	DO444	BLCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.0833
p.P866S	TCGA-E6-A1LX	UCEC	TCGA	GRTPLTSMP	DEG_APCC_DBOX_1	0.5641
p.P866S	DO41020	UCEC	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.5641
p.T853A	TCGA-EO-A3B0	UCEC	TCGA	GRTPLTSMP	DEG_APCC_DBOX_1	0.0556
p.T853A	DO219773	UCEC	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.0556
p.E862K	TCGA-FW-A3R5	SKCM	TCGA	GRTPLTSMP	DEG_APCC_DBOX_1	0.3056
p.E862K	TCGA-YD-A9TA	SKCM	TCGA	GRTPLTSMP	DEG_APCC_DBOX_1	0.3056
p.E862K	DO37406	SKCM	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.3056
p.E862K	DO219503	SKCM	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.3056
p.E862K	SIDM00841	Colorectal Carcinoma	GDSC	GRTPLTSMP	DEG_APCC_DBOX_1	0.3056
p.E862K	ACH-000651	Colon/Colorectal Cancer	CCLE	GRTPLTSMP	DEG_APCC_DBOX_1	0.3056
p.E862K	SW620	large_intestine	COSMIC	GRTPLTSMP	DEG_APCC_DBOX_1	0.3056
p.T853S	TCGA-UY-A78K	BLCA	TCGA	GRTPLTSMP	DEG_APCC_DBOX_1	0.0556
p.T853S	DO219031	BLCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.0556
p.G863E	DO222553	COCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.6087
p.G863E	DO229016	COCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.6087
p.G863E	DO52365	LUSC	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.6087
p.S861T	DO222553	COCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.2778
p.S861T	DO229013	COCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.2778
p.S861T	DO229016	COCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.2778
p.S861T	DO50851	LIRI	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.2778
p.S861T	DO230556	LUSC	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.2778
p.S861T	DO52357	LUSC	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.2778
p.P866T	DO52481	COCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.5919
p.T879S	DO229013	COCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.1111
p.T879S	DO229016	COCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.1111
p.T879S	DO228390	LICA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.1111
p.T879S	DO228531	LICA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.1111
p.T879S	DO228012	SKCA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.1111
p.A878P	DO220879	MELA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.1389
p.R864S	DO49451	PACA	ICGC	GRTPLTSMP	DEG_APCC_DBOX_1	0.7427
p.P856A	SIDM00998	Glioblastoma	GDSC	GRTPLTSMP	DEG_APCC_DBOX_1	0.1389
p.P856A	ACH-000137	Brain Cancer	CCLE	GRTPLTSMP	DEG_APCC_DBOX_1	0.1389
p.P856A	8-MG-BA	central_nervous_system	COSMIC	GRTPLTSMP	DEG_APCC_DBOX_1	0.1389
p.T868I	SIDM00391	Plasma Cell Myeloma	GDSC	GRTPLTSMP	DEG_APCC_DBOX_1	0.5966
p.T868I	ACH-000363	Myeloma	CCLE	GRTPLTSMP	DEG_APCC_DBOX_1	0.5966
p.T868I	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	GRTPLTSMP	DEG_APCC_DBOX_1	0.5966
p.T874N	SIDM01503	Small Cell Lung Carcinoma	GDSC	GRTPLTSMP	DEG_APCC_DBOX_1	0.25
p.T874N	ACH-000844	Lung Cancer	CCLE	GRTPLTSMP	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRTPLTSMP

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of GRTPLTSMP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_APCC_DBOX_1	863:871	GRTPLTSMP	APC,CDC20,FZR1	0.7787	More...