DegronMD

Uniprot ID: O14511

Source protein: Pro-neuregulin-2, membrane-bound isoform

Source gene: NRG2

Class: DEG_APCC_DBOX_1

Location: 156:164

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8845

ASA_SCORE: 57.6333

COIL: 0.3491

CONS_SCORE: 0.3756

DSS_SCORE: 0.3675

HELIX: 0.0201

FCONS_SCORE: 0.8901

RIG_SCORE: 0.8221

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V161L	TCGA-A3-3313	KIRC	TCGA	GRVALVKVL	DEG_APCC_DBOX_1	0.5654
p.R150L	TCGA-CN-4734	HNSC	TCGA	GRVALVKVL	DEG_APCC_DBOX_1	0.1667
p.R150L	DO15446	HNSC	ICGC	GRVALVKVL	DEG_APCC_DBOX_1	0.1667
p.F174L	DO50330	ESAD	ICGC	GRVALVKVL	DEG_APCC_DBOX_1	0.0556
p.N147K	DO229041	LICA	ICGC	GRVALVKVL	DEG_APCC_DBOX_1	0.0833
p.F173L	DO36394	READ	ICGC	GRVALVKVL	DEG_APCC_DBOX_1	0.0833
p.F173L	DO219773	UCEC	ICGC	GRVALVKVL	DEG_APCC_DBOX_1	0.0833
p.D165H	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	GRVALVKVL	DEG_APCC_DBOX_1	0.3056
p.D165H	SIDM00701	Non-Cancerous	GDSC	GRVALVKVL	DEG_APCC_DBOX_1	0.3056
p.D165H	ACH-000311	Lung Cancer	CCLE	GRVALVKVL	DEG_APCC_DBOX_1	0.3056
p.D165H	ACH-002370	Non-Cancerous	CCLE	GRVALVKVL	DEG_APCC_DBOX_1	0.3056
p.G172E	SIDM01782	Oral Cavity Carcinoma	GDSC	GRVALVKVL	DEG_APCC_DBOX_1	0.1111
p.G172E	ACH-000723	Head and Neck Cancer	CCLE	GRVALVKVL	DEG_APCC_DBOX_1	0.1111
p.I159N	CW-2	large_intestine	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	0.728
p.V155I	KMRC-20	kidney	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	0.3056
p.V155I	MIA-PaCa-2	pancreas	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	0.3056
p.V155I	TGW	autonomic_ganglia	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	0.3056
p.V155I	SAT	upper_aerodigestive_tract	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	0.3056
p.V155I	TE-5	oesophagus	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	0.3056
p.V155I	KALS-1	central_nervous_system	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	0.3056
p.T149P	CADO-ES1	bone	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	0.1389
p.V155F	RL95-2	endometrium	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14511	Pro-neuregulin-2, membrane-bound isoform	DEG_APCC_DBOX_1	156:164	GRVALVKVL	APC,CDC20,FZR1	0.8845	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons