DegronMD - O14511(NRG2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R236P	TCGA-66-2787	LUSC	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7512
p.R236P	DO26647	LUSC	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7512
p.V161L	TCGA-A3-3313	KIRC	TCGA	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation altering degron motif	0.5654
p.T246M	TCGA-AA-A01R	COAD	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.25
p.T246M	TCGA-D9-A6EG	SKCM	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.25
p.T246M	DO7934	COAD	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.25
p.T246M	DO50292	SKCM	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.25
p.K241N	TCGA-AO-A03M	BRCA	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.5806
p.K241N	DO2216	BRCA	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.5806
p.K243N	TCGA-B5-A11E	UCEC	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.5806
p.K243N	DO41644	UCEC	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.5806
p.R150L	TCGA-CN-4734	HNSC	TCGA	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.1667
p.R150L	DO15446	HNSC	ICGC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.1667
p.G247E	TCGA-EE-A2MU	SKCM	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2222
p.G247E	DO37436	SKCM	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2222
p.Y755C	DO230311	COCA	ICGC	RRSRLNGLA	DEG_APCC_DBOX_1	744:752	Mutation rewiring degron network	0.25
p.F174L	DO50330	ESAD	ICGC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.0556
p.N147K	DO229041	LICA	ICGC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.0833
p.V225M	DO231620	LINC	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0556
p.F173L	DO36394	READ	ICGC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.0833
p.F173L	DO219773	UCEC	ICGC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.0833
p.C233S	DO229234	THCA	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2778
p.D165H	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.D165H	SIDM00701	Non-Cancerous	GDSC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.D165H	ACH-000311	Lung Cancer	CCLE	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.D165H	ACH-002370	Non-Cancerous	CCLE	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.M242I	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.6507
p.M242I	ACH-002264	Esophageal Cancer	CCLE	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.6507
p.M242I	KYSE-50	oesophagus	COSMIC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.6507
p.G172E	SIDM01782	Oral Cavity Carcinoma	GDSC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.1111
p.G172E	ACH-000723	Head and Neck Cancer	CCLE	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.1111
p.I159N	CW-2	large intestine	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation altering degron motif	0.728
p.V155I	KMRC-20	kidney	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.V155I	MIA-PaCa-2	pancreas	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.V155I	TGW	autonomic ganglia	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.V155I	SAT	upper aerodigestive tract	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.V155I	TE-5	oesophagus	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.V155I	KALS-1	central nervous system	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056
p.P244L	SCH	stomach	COSMIC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.3056
p.P244L	RERF-LC-FM	lung	COSMIC	TRPKLKKMK	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.3056
p.T149P	CADO-ES1	bone	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.1389
p.V155F	RL95-2	endometrium	COSMIC	GRVALVKVL	DEG_APCC_DBOX_1	156:164	Mutation rewiring degron network	0.3056

Kaplan plot for NRG2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRG2

UniProt ID: O14511

Entrez ID: 9542

Protein name: Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRG2 in