DegronMD

Uniprot ID: O14511

Source protein: Pro-neuregulin-2, membrane-bound isoform

Source gene: NRG2

Class: DEG_APCC_DBOX_1

Location: 235:243

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9931

ASA_SCORE: 95.7889

COIL: 0.6668

CONS_SCORE: 0.582

DSS_SCORE: 0.3785

HELIX: 0.146

FCONS_SCORE: 1.2561

RIG_SCORE: 0.7881

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R236P	TCGA-66-2787	LUSC	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	0.7512
p.R236P	DO26647	LUSC	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	0.7512
p.T246M	TCGA-AA-A01R	COAD	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	0.25
p.T246M	TCGA-D9-A6EG	SKCM	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	0.25
p.T246M	DO7934	COAD	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	0.25
p.T246M	DO50292	SKCM	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	0.25
p.K241N	TCGA-AO-A03M	BRCA	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	0.5806
p.K241N	DO2216	BRCA	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	0.5806
p.K243N	TCGA-B5-A11E	UCEC	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	0.5806
p.K243N	DO41644	UCEC	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	0.5806
p.G247E	TCGA-EE-A2MU	SKCM	TCGA	TRPKLKKMK	DEG_APCC_DBOX_1	0.2222
p.G247E	DO37436	SKCM	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	0.2222
p.V225M	DO231620	LINC	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	0.0556
p.C233S	DO229234	THCA	ICGC	TRPKLKKMK	DEG_APCC_DBOX_1	0.2778
p.M242I	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	TRPKLKKMK	DEG_APCC_DBOX_1	0.6507
p.M242I	ACH-002264	Esophageal Cancer	CCLE	TRPKLKKMK	DEG_APCC_DBOX_1	0.6507
p.M242I	KYSE-50	oesophagus	COSMIC	TRPKLKKMK	DEG_APCC_DBOX_1	0.6507
p.P244L	SCH	stomach	COSMIC	TRPKLKKMK	DEG_APCC_DBOX_1	0.3056
p.P244L	RERF-LC-FM	lung	COSMIC	TRPKLKKMK	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14511	Pro-neuregulin-2, membrane-bound isoform	DEG_APCC_DBOX_1	235:243	TRPKLKKMK	APC,CDC20,FZR1	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons