DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
GRVKLRKIV
Uniprot ID:
B2RXH4
Source protein:
BTB/POZ domain-containing protein 18
Source gene:
BTBD18
Class:
DEG_APCC_DBOX_1
Location:
356:364
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7624
ASA_SCORE:
78.3333
COIL:
0.338
CONS_SCORE:
0.4324
DSS_SCORE:
0.4118
HELIX:
0.0269
FCONS_SCORE:
1.0165
RIG_SCORE:
0.7926
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E351D
TCGA-DF-A2KU
UCEC
TCGA
GRVKLRKIV
DEG_APCC_DBOX_1
0.1944
p.E351D
DO223286
UCEC
ICGC
GRVKLRKIV
DEG_APCC_DBOX_1
0.1944
Drug responses associated with BTBD18 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GRVKLRKIV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
B2RXH4
BTB/POZ domain-containing protein 18
DEG_APCC_DBOX_1
356:364
GRVKLRKIV
APC,CDC20,FZR1
0.7624
More...