DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
GRVKLRKIV
Uniprot ID:
B2RXH4
Source protein:
BTB/POZ domain-containing protein 18
Source gene:
BTBD18
Class:
DEG_APCC_DBOX_1
Location:
356:364
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7624
ASA_SCORE:
78.3333
COIL:
0.338
CONS_SCORE:
0.4324
DSS_SCORE:
0.4118
HELIX:
0.0269
FCONS_SCORE:
1.0165
RIG_SCORE:
0.7926
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E351D
TCGA-DF-A2KU
UCEC
TCGA
GRVKLRKIV
DEG_APCC_DBOX_1
0.1944
p.E351D
DO223286
UCEC
ICGC
GRVKLRKIV
DEG_APCC_DBOX_1
0.1944
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Drug responses associated with BTBD18 mutations
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Cancer
Mutation (In Degron?)
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Drug
IC50
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All proteins holding degron of GRVKLRKIV
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
B2RXH4
BTB/POZ domain-containing protein 18
DEG_APCC_DBOX_1
356:364
GRVKLRKIV
APC,CDC20,FZR1
0.7624
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