DegronMD - B2RXH4(BTBD18)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D310G	TCGA-AX-A1CE	UCEC	TCGA	LQSTPNPS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.0556
p.D310G	DO42280	UCEC	ICGC	LQSTPNPS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.0556
p.L611V	TCGA-BH-A0B6	BRCA	TCGA	LDTPQRS	DEG_SCF_FBW7_1	616:622	Mutation rewiring degron network	0.1944
p.L611V	DO2641	BRCA	ICGC	LDTPQRS	DEG_SCF_FBW7_1	616:622	Mutation rewiring degron network	0.1944
p.L626P	TCGA-D8-A1XK	BRCA	TCGA	LDTPQRS	DEG_SCF_FBW7_1	616:622	Mutation rewiring degron network	0.2222
p.L626P	DO4749	BRCA	ICGC	LDTPQRS	DEG_SCF_FBW7_1	616:622	Mutation rewiring degron network	0.2222
p.E351D	TCGA-DF-A2KU	UCEC	TCGA	GRVKLRKIV	DEG_APCC_DBOX_1	356:364	Mutation rewiring degron network	0.1944
p.E351D	DO223286	UCEC	ICGC	GRVKLRKIV	DEG_APCC_DBOX_1	356:364	Mutation rewiring degron network	0.1944
p.R155K	DO1076	BRCA	ICGC	PHTPLPT	DEG_SCF_FBW7_1	163:169	Mutation rewiring degron network	0.1111
p.I179V	DO50401	ESAD	ICGC	PHTPLPT	DEG_SCF_FBW7_1	163:169	Mutation rewiring degron network	0.0556
p.L167Q	DO228206	LICA	ICGC	PHTPLPT	DEG_SCF_FBW7_1	163:169	Mutation altering degron motif	0.6654
p.G624R	DO23838	LUAD	ICGC	LDTPQRS	DEG_SCF_FBW7_1	616:622	Mutation rewiring degron network	0.2778
p.P166S	DO231183	LUSC	ICGC	PHTPLPT	DEG_SCF_FBW7_1	163:169	Mutation altering degron motif	0.6752
p.Q620H	DO27326	LUSC	ICGC	LDTPQRS	DEG_SCF_FBW7_1	616:622	Mutation altering degron motif	0.647
p.R621M	ACH-000911	Gastric Cancer	CCLE	LDTPQRS	DEG_SCF_FBW7_1	616:622	Mutation altering degron motif	0.7521

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons