DegronMD

Uniprot ID: B2RXH4

Source protein: BTB/POZ domain-containing protein 18

Source gene: BTBD18

Class: DEG_SCF_FBW7_1

Location: 616:622

E3 ligase: FBXW7

DEGRON score: 0.8906

ASA_SCORE: 87.4857

COIL: 0.9293

CONS_SCORE: 0.4403

DSS_SCORE: 0.49

HELIX: 0.0243

FCONS_SCORE: 0.9829

RIG_SCORE: 0.6823

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L611V	TCGA-BH-A0B6	BRCA	TCGA	LDTPQRS	DEG_SCF_FBW7_1	0.1944
p.L611V	DO2641	BRCA	ICGC	LDTPQRS	DEG_SCF_FBW7_1	0.1944
p.L626P	TCGA-D8-A1XK	BRCA	TCGA	LDTPQRS	DEG_SCF_FBW7_1	0.2222
p.L626P	DO4749	BRCA	ICGC	LDTPQRS	DEG_SCF_FBW7_1	0.2222
p.G624R	DO23838	LUAD	ICGC	LDTPQRS	DEG_SCF_FBW7_1	0.2778
p.Q620H	DO27326	LUSC	ICGC	LDTPQRS	DEG_SCF_FBW7_1	0.647
p.R621M	ACH-000911	Gastric Cancer	CCLE	LDTPQRS	DEG_SCF_FBW7_1	0.7521

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B2RXH4	BTB/POZ domain-containing protein 18	DEG_SCF_FBW7_1	616:622	LDTPQRS	FBXW7	0.8906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons