DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LQSTPNPS
Uniprot ID:
B2RXH4
Source protein:
BTB/POZ domain-containing protein 18
Source gene:
BTBD18
Class:
DEG_SCF_FBW7_1
Location:
320:327
E3 ligase:
FBXW7
DEGRON score:
0.9917
ASA_SCORE:
83.2125
COIL:
0.9203
CONS_SCORE:
0.4288
DSS_SCORE:
0.8572
HELIX:
0.0378
FCONS_SCORE:
1.0742
RIG_SCORE:
0.5309
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D310G
TCGA-AX-A1CE
UCEC
TCGA
LQSTPNPS
DEG_SCF_FBW7_1
0.0556
p.D310G
DO42280
UCEC
ICGC
LQSTPNPS
DEG_SCF_FBW7_1
0.0556
Drug responses associated with BTBD18 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQSTPNPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
B2RXH4
BTB/POZ domain-containing protein 18
DEG_SCF_FBW7_1
320:327
LQSTPNPS
FBXW7
0.9917
More...