DegronMD

Uniprot ID: B2RXH4

Source protein: BTB/POZ domain-containing protein 18

Source gene: BTBD18

Class: DEG_SCF_FBW7_1

Location: 163:169

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 105.2857

COIL: 0.9734

CONS_SCORE: 0.5056

DSS_SCORE: 0.6829

HELIX: 0.0139

FCONS_SCORE: 1.1445

RIG_SCORE: 0.6114

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R155K	DO1076	BRCA	ICGC	PHTPLPT	DEG_SCF_FBW7_1	0.1111
p.I179V	DO50401	ESAD	ICGC	PHTPLPT	DEG_SCF_FBW7_1	0.0556
p.L167Q	DO228206	LICA	ICGC	PHTPLPT	DEG_SCF_FBW7_1	0.6654
p.P166S	DO231183	LUSC	ICGC	PHTPLPT	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B2RXH4	BTB/POZ domain-containing protein 18	DEG_SCF_FBW7_1	163:169	PHTPLPT	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons