DegronMD

Uniprot ID: Q14839

Source protein: Chromodomain-helicase-DNA-binding protein 4

Source gene: CHD4

Class: DEG_SCF_SKP2-CKS1_1

Location: 107:114

E3 ligase: SKP2,CSK1

DEGRON score: 0.9635

ASA_SCORE: 86.8625

COIL: 0.8959

CONS_SCORE: 0.251

DSS_SCORE: 0.5616

HELIX: 0.0613

FCONS_SCORE: 1.0539

RIG_SCORE: 0.6006

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P112L	TCGA-NC-A5HN	LUSC	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P105L	DO52025	LUSC	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.7222
p.Y110C	TCGA-KK-A8I6	PRAD	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.7087
p.S108N	TCGA-XF-AAMG	BLCA	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.7069
p.D109N	TCGA-B5-A11E	UCEC	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.6932
p.Y103C	DO219317	PRAD	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.6667
p.E106G	TCGA-17-Z023	LUAD	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.D104Y	TCGA-XF-AAMG	BLCA	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.R102C	TCGA-D8-A1XK	BRCA	TCGA	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S123F	DO50281	SKCM	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S123F	DO219482	SKCM	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.D102N	DO41644	UCEC	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.R102H	SIDM00760	Small Cell Lung Carcinoma	GDSC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.R102H	NCI-H1963	lung	COSMIC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S101N	DO219049	BLCA	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R99H	NCI-H1963	lung	COSMIC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.D97Y	DO219049	BLCA	ICGC	GSDYTPGK	DEG_SCF_SKP2-CKS1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14839	Chromodomain-helicase-DNA-binding protein 4	DEG_SCF_SKP2-CKS1_1	107:114	GSDYTPGK	SKP2,CSK1	0.9635	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons