DegronMD

Uniprot ID: Q32MH5

Source protein: Protein FAM214A

Source gene: FAM214A

Class: DEG_APCC_KENBOX_2

Location: 617:621

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8235

ASA_SCORE: 108.16

COIL: 0.6976

CONS_SCORE: 0.2751

DSS_SCORE: 0.4885

HELIX: 0.2716

FCONS_SCORE: 0.9351

RIG_SCORE: 0.6949

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S609L	TCGA-A5-A0G2	UCEC	TCGA	HKENN	DEG_APCC_KENBOX_2	0.1111
p.S609L	DO41235	UCEC	ICGC	HKENN	DEG_APCC_KENBOX_2	0.1111
p.S611F	TCGA-VS-A8EL	CESC	TCGA	HKENN	DEG_APCC_KENBOX_2	0.1667
p.T617A	DO48416	BLCA	ICGC	HKENN	DEG_APCC_KENBOX_2	0.7139
p.T617A	DO229010	COCA	ICGC	HKENN	DEG_APCC_KENBOX_2	0.7139
p.T617A	DO229013	COCA	ICGC	HKENN	DEG_APCC_KENBOX_2	0.7139
p.T617A	DO229016	COCA	ICGC	HKENN	DEG_APCC_KENBOX_2	0.7139
p.T617A	DO229003	COCA	ICGC	HKENN	DEG_APCC_KENBOX_2	0.7139
p.T617A	DO229005	COCA	ICGC	HKENN	DEG_APCC_KENBOX_2	0.7139
p.T617A	DO223106	ESCA	ICGC	HKENN	DEG_APCC_KENBOX_2	0.7139
p.S618F	DO51624	CESC	ICGC	HKENN	DEG_APCC_KENBOX_2	0.7982
p.S612I	DO233148	GACA	ICGC	HKENN	DEG_APCC_KENBOX_2	0.1944
p.S607C	DO228229	LICA	ICGC	HKENN	DEG_APCC_KENBOX_2	0.5
p.S612N	DO41020	UCEC	ICGC	HKENN	DEG_APCC_KENBOX_2	0.1944
p.N627I	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	HKENN	DEG_APCC_KENBOX_2	0.1667
p.F628L	ACH-000788	Skin Cancer	CCLE	HKENN	DEG_APCC_KENBOX_2	0.1389
p.F628L	A2058	skin	COSMIC	HKENN	DEG_APCC_KENBOX_2	0.1389
p.N620I	ACH-000891	Lung Cancer	CCLE	HKENN	DEG_APCC_KENBOX_2	0.728
p.I613V	ACH-001814	Bone Cancer	CCLE	HKENN	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q32MH5	Protein FAM214A	DEG_APCC_KENBOX_2	617:621	HKENN	APC,CDC20,FZR1	0.8235	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons