DegronMD - Q32MH5(FAM214A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S609L	TCGA-A5-A0G2	UCEC	TCGA	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1111
p.S609L	DO41235	UCEC	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1111
p.R453Q	TCGA-A5-A0G2	UCEC	TCGA	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation altering degron motif	0.6218
p.R453Q	TCGA-AX-A0J0	UCEC	TCGA	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation altering degron motif	0.6218
p.R453Q	DO41235	UCEC	ICGC	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation altering degron motif	0.6218
p.R453Q	DO41133	UCEC	ICGC	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation altering degron motif	0.6218
p.P449Q	TCGA-EE-A3AC	SKCM	TCGA	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation altering degron motif	0.7035
p.D461G	TCGA-P5-A780	LGG	TCGA	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation rewiring degron network	0.1667
p.S611F	TCGA-VS-A8EL	CESC	TCGA	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.T617A	DO48416	BLCA	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7139
p.T617A	DO229010	COCA	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7139
p.T617A	DO229013	COCA	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7139
p.T617A	DO229016	COCA	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7139
p.T617A	DO229003	COCA	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7139
p.T617A	DO229005	COCA	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7139
p.T617A	DO223106	ESCA	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7139
p.S618F	DO51624	CESC	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.7982
p.S612I	DO233148	GACA	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1944
p.S607C	DO228229	LICA	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation blocking phosphorylation signal	0.5
p.P456Q	DO37631	SKCM	ICGC	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation rewiring degron network	0.3056
p.S612N	DO41020	UCEC	ICGC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1944
p.D446Y	SIDM00193	Colorectal Carcinoma	GDSC	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation rewiring degron network	0.25
p.D446Y	SNU-81	large intestine	COSMIC	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation rewiring degron network	0.25
p.N627I	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1667
p.F628L	ACH-000788	Skin Cancer	CCLE	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1389
p.F628L	A2058	skin	COSMIC	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.1389
p.N620I	ACH-000891	Lung Cancer	CCLE	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation altering degron motif	0.728
p.D439Y	ACH-000991	Colon/Colorectal Cancer	CCLE	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation rewiring degron network	0.0556
p.D439Y	SNU-81	large intestine	COSMIC	PETPRSE	DEG_SCF_FBW7_2	449:455	Mutation rewiring degron network	0.0556
p.I613V	ACH-001814	Bone Cancer	CCLE	HKENN	DEG_APCC_KENBOX_2	617:621	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM214A

UniProt ID: Q32MH5

Entrez ID: 56204

Protein name: Protein FAM214A

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FAM214A in