DegronMD

Uniprot ID: Q32MH5

Source protein: Protein FAM214A

Source gene: FAM214A

Class: DEG_SCF_FBW7_2

Location: 449:455

E3 ligase: FBXW7

DEGRON score: 0.9905

ASA_SCORE: 97.1429

COIL: 0.8857

CONS_SCORE: 0.3842

DSS_SCORE: 0.551

HELIX: 0.083

FCONS_SCORE: 1.2528

RIG_SCORE: 0.6939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R453Q	TCGA-A5-A0G2	UCEC	TCGA	PETPRSE	DEG_SCF_FBW7_2	0.6218
p.R453Q	TCGA-AX-A0J0	UCEC	TCGA	PETPRSE	DEG_SCF_FBW7_2	0.6218
p.R453Q	DO41235	UCEC	ICGC	PETPRSE	DEG_SCF_FBW7_2	0.6218
p.R453Q	DO41133	UCEC	ICGC	PETPRSE	DEG_SCF_FBW7_2	0.6218
p.P449Q	TCGA-EE-A3AC	SKCM	TCGA	PETPRSE	DEG_SCF_FBW7_2	0.7035
p.D461G	TCGA-P5-A780	LGG	TCGA	PETPRSE	DEG_SCF_FBW7_2	0.1667
p.P456Q	DO37631	SKCM	ICGC	PETPRSE	DEG_SCF_FBW7_2	0.3056
p.D446Y	SIDM00193	Colorectal Carcinoma	GDSC	PETPRSE	DEG_SCF_FBW7_2	0.25
p.D446Y	SNU-81	large_intestine	COSMIC	PETPRSE	DEG_SCF_FBW7_2	0.25
p.D439Y	ACH-000991	Colon/Colorectal Cancer	CCLE	PETPRSE	DEG_SCF_FBW7_2	0.0556
p.D439Y	SNU-81	large_intestine	COSMIC	PETPRSE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q32MH5	Protein FAM214A	DEG_SCF_FBW7_2	449:455	PETPRSE	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons