DegronMD

Uniprot ID: O00478

Source protein: Butyrophilin subfamily 3 member A3

Source gene: BTN3A3

Class: DEG_SIAH_1

Location: 559:567

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9691

ASA_SCORE: 65.4

COIL: 0.8816

CONS_SCORE: 0.1941

DSS_SCORE: 0.6356

HELIX: 0.0704

FCONS_SCORE: 0.9473

RIG_SCORE: 0.6235

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P566T	TCGA-55-6971	LUAD	TCGA	HPGAEVSPS	DEG_SIAH_1	0.7031
p.P566T	TCGA-DA-A1I7	SKCM	TCGA	HPGAEVSPS	DEG_SIAH_1	0.7031
p.L576V	TCGA-AP-A0LH	UCEC	TCGA	HPGAEVSPS	DEG_SIAH_1	0.0833
p.N573S	TCGA-B0-5400	KIRC	TCGA	HPGAEVSPS	DEG_SIAH_1	0.1667
p.H559N	TCGA-BQ-7044	KIRP	TCGA	HPGAEVSPS	DEG_SIAH_1	0.6312
p.S565F	TCGA-CQ-5327	HNSC	TCGA	HPGAEVSPS	DEG_SIAH_1	0.6871
p.E550K	TCGA-FR-A726	SKCM	TCGA	HPGAEVSPS	DEG_SIAH_1	0.0833
p.L554V	TCGA-MV-A51V	BLCA	TCGA	HPGAEVSPS	DEG_SIAH_1	0.1944
p.T569A	SIDM00474	Ovarian Carcinoma	GDSC	HPGAEVSPS	DEG_SIAH_1	0.2778
p.T569A	OV-7	ovary	COSMIC	HPGAEVSPS	DEG_SIAH_1	0.2778
p.P560L	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	HPGAEVSPS	DEG_SIAH_1	0.7582
p.P560L	NCI-H1155	lung	COSMIC	HPGAEVSPS	DEG_SIAH_1	0.7582
p.H559Q	ACH-000995	Leukemia	CCLE	HPGAEVSPS	DEG_SIAH_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00478	Butyrophilin subfamily 3 member A3	DEG_SIAH_1	559:567	HPGAEVSPS	SIAH1,SIAH2,SIAH3	0.9691	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons