DegronMD - O00478(BTN3A3)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P566T	TCGA-55-6971	LUAD	TCGA	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation altering degron motif	0.7031
p.P566T	TCGA-DA-A1I7	SKCM	TCGA	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation altering degron motif	0.7031
p.L576V	TCGA-AP-A0LH	UCEC	TCGA	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation rewiring degron network	0.0833
p.V461A	TCGA-AX-A2HD	UCEC	TCGA	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation altering degron motif	0.6936
p.N573S	TCGA-B0-5400	KIRC	TCGA	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation rewiring degron network	0.1667
p.T469P	TCGA-BH-A0HU	BRCA	TCGA	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.25
p.H559N	TCGA-BQ-7044	KIRP	TCGA	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation altering degron motif	0.6312
p.S565F	TCGA-CQ-5327	HNSC	TCGA	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation altering degron motif	0.6871
p.E468D	TCGA-D8-A1J9	BRCA	TCGA	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.2778
p.P458S	TCGA-EE-A181	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.25
p.E550K	TCGA-FR-A726	SKCM	TCGA	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation rewiring degron network	0.0833
p.E468Q	TCGA-G2-AA3D	BLCA	TCGA	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.2778
p.L554V	TCGA-MV-A51V	BLCA	TCGA	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation rewiring degron network	0.1944
p.V469A	DO224684	BRCA	ICGC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.25
p.P457A	DO227709	COCA	ICGC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.2222
p.L460M	DO227709	COCA	ICGC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.3056
p.L453F	DO14188	HNSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation substituting flanking lysine	0.2222
p.K467E	DO52030	HNSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.3056
p.A459S	DO229009	LICA	ICGC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.2778
p.E456Q	DO223721	LUSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.1944
p.R451I	DO47763	STAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.0556
p.V469E	DO42177	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.25
p.S472F	DO42713	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.1667
p.K460N	SIDM02029	Colorectal Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.3056
p.T569A	SIDM00474	Ovarian Carcinoma	GDSC	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation rewiring degron network	0.2778
p.T569A	OV-7	ovary	COSMIC	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation rewiring degron network	0.2778
p.N451S	SIDM00963	Breast Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.0556
p.P560L	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation altering degron motif	0.7582
p.P560L	NCI-H1155	lung	COSMIC	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation altering degron motif	0.7582
p.I463V	SIDM00168	Head and Neck Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation altering degron motif	0.5965
p.I463V	SIDM00173	Head and Neck Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation altering degron motif	0.5965
p.F464I	SIDM00168	Head and Neck Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation altering degron motif	0.7415
p.F464I	SIDM00173	Head and Neck Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation altering degron motif	0.7415
p.H559Q	ACH-000995	Leukemia	CCLE	HPGAEVSPS	DEG_SIAH_1	559:567	Mutation altering degron motif	0.647
p.T454I	ACH-001696	Head and Neck Cancer	CCLE	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.1389
p.P457T	ACH-002280	Neuroblastoma	CCLE	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.2222
p.P457T	NB13	autonomic ganglia	COSMIC	VGIFLD	LIG_APCC_ABBA_1	461:466	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BTN3A3

UniProt ID: O00478

Entrez ID: 10384

Protein name: Butyrophilin subfamily 3 member A3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BTN3A3 in