DegronMD

Uniprot ID: O00478

Source protein: Butyrophilin subfamily 3 member A3

Source gene: BTN3A3

Class: LIG_APCC_ABBA_1

Location: 461:466

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5632

ASA_SCORE: 11.75

COIL: 0.0203

CONS_SCORE: 0.7147

DSS_SCORE: 0.3013

HELIX: 0.0015

FCONS_SCORE: 1.362

RIG_SCORE: 0.854

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F464I	SIDM00168	Head and Neck Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	0.7415
p.F464I	SIDM00173	Head and Neck Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	0.7415
p.V461A	TCGA-AX-A2HD	UCEC	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.6936
p.I463V	SIDM00168	Head and Neck Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	0.5965
p.I463V	SIDM00173	Head and Neck Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	0.5965
p.L460M	DO227709	COCA	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.3056
p.K467E	DO52030	HNSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.3056
p.K460N	SIDM02029	Colorectal Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	0.3056
p.E468D	TCGA-D8-A1J9	BRCA	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.2778
p.E468Q	TCGA-G2-AA3D	BLCA	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.2778
p.A459S	DO229009	LICA	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.2778
p.T469P	TCGA-BH-A0HU	BRCA	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.25
p.P458S	TCGA-EE-A181	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.25
p.V469A	DO224684	BRCA	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.25
p.V469E	DO42177	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.25
p.P457A	DO227709	COCA	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.2222
p.L453F	DO14188	HNSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.2222
p.P457T	ACH-002280	Neuroblastoma	CCLE	VGIFLD	LIG_APCC_ABBA_1	0.2222
p.P457T	NB13	autonomic_ganglia	COSMIC	VGIFLD	LIG_APCC_ABBA_1	0.2222
p.E456Q	DO223721	LUSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.1944
p.S472F	DO42713	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.1667
p.T454I	ACH-001696	Head and Neck Cancer	CCLE	VGIFLD	LIG_APCC_ABBA_1	0.1389
p.R451I	DO47763	STAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.0556
p.N451S	SIDM00963	Breast Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	0.0556

Showing 1 to 24 of 24 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00478	Butyrophilin subfamily 3 member A3	LIG_APCC_ABBA_1	461:466	VGIFLD	APC,CDC20,FZR1	0.5632	More...
Q9HCM9	E3 ubiquitin-protein ligase TRIM39	LIG_APCC_ABBA_1	458:463	VGIFLD	APC,CDC20,FZR1	0.6444	More...
O75677	Ret finger protein-like 1	LIG_APCC_ABBA_1	245:250	VGIFLD	APC,CDC20,FZR1	0.6529	More...
O75678	Ret finger protein-like 2	LIG_APCC_ABBA_1	306:311	VGIFLD	APC,CDC20,FZR1	0.6529	More...
O75679	Ret finger protein-like 3	LIG_APCC_ABBA_1	245:250	VGIFLD	APC,CDC20,FZR1	0.5402	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons