DegronMD - Q9HCM9(TRIM39)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L449F	TCGA-06-1805	GBM	TCGA	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.0833
p.L449F	TCGA-06-1805	GBM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation rewiring degron network	0.1111
p.I451T	TCGA-B5-A3FA	UCEC	TCGA	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.1389
p.I451T	TCGA-B5-A3FA	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation rewiring degron network	0.1667
p.R457Q	TCGA-CK-4952	COAD	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation altering degron motif	0.7329
p.T468A	TCGA-DI-A1BU	UCEC	TCGA	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation blocking phosphorylation signal	0.6389
p.T468A	TCGA-DI-A1BU	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation blocking phosphorylation signal	0.6389
p.A466V	TCGA-FW-A3TU	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.25
p.A466V	TCGA-FW-A3TU	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation rewiring degron network	0.25
p.R447H	DO233696	GACA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation rewiring degron network	0.0556
p.R447H	ARH-77	haematopoietic and lymphoid tissue	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation rewiring degron network	0.0556
p.P467S	DO14160	HNSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.2222
p.P467S	DO14160	HNSC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation rewiring degron network	0.2222
p.P467S	DO26435	LUSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.2222
p.P467S	DO26435	LUSC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation rewiring degron network	0.2222
p.W462C	DO24100	LUAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.7
p.W462C	DO24100	LUAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation altering degron motif	0.7
p.E459K	DO219165	LUSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation altering degron motif	0.7022
p.E459K	DO219165	LUSC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation altering degron motif	0.7022
p.R470W	DO51766	STAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.1389
p.R470W	DO51766	STAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation rewiring degron network	0.1389
p.R470Q	DO42753	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.1389
p.R470Q	DO42753	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation rewiring degron network	0.1389
p.R470L	NCI-H1623	lung	COSMIC	VGIFLD	LIG_APCC_ABBA_1	458:463	Mutation rewiring degron network	0.1389
p.R470L	NCI-H1623	lung	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	457:463	Mutation rewiring degron network	0.1389

Kaplan plot for TRIM39 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM39

UniProt ID: Q9HCM9

Entrez ID: 56658

Protein name: E3 ubiquitin-protein ligase TRIM39 (EC 2.3.2.27) (RING finger protein 23) (RING-type E3 ubiquitin transferase TRIM39) (Testis-abundant finger protein) (Tripartite motif-containing protein 39)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM39 in