DegronMD

Uniprot ID: Q9HCM9

Source protein: E3 ubiquitin-protein ligase TRIM39

Source gene: TRIM39

Class: LIG_APCC_ABBA_1

Location: 458:463

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6444

ASA_SCORE: 9.6833

COIL: 0.0468

CONS_SCORE: 0.7722

DSS_SCORE: 0.0678

HELIX: 0.0028

FCONS_SCORE: 1.2183

RIG_SCORE: 0.9102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L449F	TCGA-06-1805	GBM	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.0833
p.I451T	TCGA-B5-A3FA	UCEC	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.1389
p.T468A	TCGA-DI-A1BU	UCEC	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.6389
p.A466V	TCGA-FW-A3TU	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.25
p.P467S	DO14160	HNSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.2222
p.P467S	DO26435	LUSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.2222
p.W462C	DO24100	LUAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.7
p.E459K	DO219165	LUSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.7022
p.R470W	DO51766	STAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.1389
p.R470Q	DO42753	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.1389
p.R470L	NCI-H1623	lung	COSMIC	VGIFLD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00478	Butyrophilin subfamily 3 member A3	LIG_APCC_ABBA_1	461:466	VGIFLD	APC,CDC20,FZR1	0.5632	More...
O75677	Ret finger protein-like 1	LIG_APCC_ABBA_1	245:250	VGIFLD	APC,CDC20,FZR1	0.6529	More...
O75679	Ret finger protein-like 3	LIG_APCC_ABBA_1	245:250	VGIFLD	APC,CDC20,FZR1	0.5402	More...
Q9HCM9	E3 ubiquitin-protein ligase TRIM39	LIG_APCC_ABBA_1	458:463	VGIFLD	APC,CDC20,FZR1	0.6444	More...
O75678	Ret finger protein-like 2	LIG_APCC_ABBA_1	306:311	VGIFLD	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons