DegronMD - O75679(RFPL3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F248Y	TCGA-55-A490	LUAD	TCGA	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.6417
p.F248Y	TCGA-55-A490	LUAD	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.6417
p.R240H	TCGA-A5-A0G2	UCEC	TCGA	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.R240H	TCGA-A5-A0G2	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.2222
p.R240H	TCGA-AX-A1CE	UCEC	TCGA	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.R240H	TCGA-AX-A1CE	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.2222
p.R240H	SIDM02059	Colorectal Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.R240H	SIDM02059	Colorectal Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.2222
p.R240H	SIDM02013	Colorectal Carcinoma	GDSC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.R240H	SIDM02013	Colorectal Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.2222
p.R240H	SIDM00720	Mesothelioma	GDSC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.R240H	SIDM00720	Mesothelioma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.2222
p.R240H	ACH-000648	Lung Cancer	CCLE	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.R240H	ACH-000648	Lung Cancer	CCLE	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.2222
p.R240H	NCI-H28	pleura	COSMIC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.R240H	NCI-H28	pleura	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.2222
p.V245L	TCGA-D1-A17Q	UCEC	TCGA	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.5654
p.V245L	TCGA-D1-A17Q	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.5654
p.G246E	TCGA-D9-A1JW	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.6087
p.G246E	TCGA-D9-A1JW	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.6087
p.R251H	DO7855	COAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.R251H	DO7855	COAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.3056
p.R251H	DO41799	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.R251H	DO41799	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.3056
p.R251C	DO222733	COCA	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.R251C	DO222733	COCA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.3056
p.R251C	DO222813	COCA	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.R251C	DO222813	COCA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.3056
p.R251C	DO225404	LAML	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.R251C	DO225404	LAML	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.3056
p.R251C	DO51022	LAML	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.R251C	DO51022	LAML	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.3056
p.R251C	DO228941	LICA	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.R251C	DO228941	LICA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.3056
p.R251C	DO32980	PACA	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.R251C	DO32980	PACA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.3056
p.R251C	DO229472	PRAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.R251C	DO229472	PRAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.3056
p.V244I	DO14293	HNSC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7076
p.S234G	DO225404	LAML	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.0556
p.S234G	DO228941	LICA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.0556
p.L250Q	DO25787	LUAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.7765
p.L250Q	DO25787	LUAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.7765
p.S243R	DO45346	LUAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.2778
p.S243R	DO45346	LUAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.3056
p.P256H	DO42193	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1667
p.P256H	DO42193	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.1667
p.V245A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.6936
p.V245A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.5825
p.V245A	ACH-000937	Leukemia	CCLE	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.6936
p.V245A	ACH-000937	Leukemia	CCLE	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.5825
p.V245A	PF-382	haematopoietic and lymphoid tissue	COSMIC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.6936
p.V245A	PF-382	haematopoietic and lymphoid tissue	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation altering degron motif	0.5825
p.L237F	SIDM00959	Acute Myeloid Leukemia	GDSC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.L237F	SIDM00959	Acute Myeloid Leukemia	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation rewiring degron network	0.1389
p.F241C	ACH-002256	Leukemia	CCLE	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation substituting flanking lysine	0.3333
p.F241C	ACH-002256	Leukemia	CCLE	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation substituting flanking lysine	0.3611
p.F241C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VGIFLD	LIG_APCC_ABBA_1	245:250	Mutation substituting flanking lysine	0.3333
p.F241C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	244:250	Mutation substituting flanking lysine	0.3611

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFPL3

UniProt ID: O75679

Entrez ID: 10738

Protein name: Ret finger protein-like 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFPL3 in