DegronMD

Uniprot ID: O75679

Source protein: Ret finger protein-like 3

Source gene: RFPL3

Class: LIG_APCC_ABBAyCdc20_2

Location: 244:250

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5054

ASA_SCORE: 19.2143

COIL: 0.026

CONS_SCORE: 0.9161

DSS_SCORE: 0.0366

HELIX: 0.0024

FCONS_SCORE: 1.4304

RIG_SCORE: 0.9238

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F248Y	TCGA-55-A490	LUAD	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.6417
p.R240H	TCGA-A5-A0G2	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240H	TCGA-AX-A1CE	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240H	SIDM02059	Colorectal Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240H	SIDM02013	Colorectal Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240H	SIDM00720	Mesothelioma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240H	ACH-000648	Lung Cancer	CCLE	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240H	NCI-H28	pleura	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V245L	TCGA-D1-A17Q	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.5654
p.G246E	TCGA-D9-A1JW	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.6087
p.R251H	DO7855	COAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R251H	DO41799	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R251C	DO222733	COCA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R251C	DO222813	COCA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R251C	DO225404	LAML	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R251C	DO51022	LAML	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R251C	DO228941	LICA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R251C	DO32980	PACA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R251C	DO229472	PRAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.V244I	DO14293	HNSC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7076
p.S234G	DO225404	LAML	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.S234G	DO228941	LICA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.L250Q	DO25787	LUAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7765
p.S243R	DO45346	LUAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P256H	DO42193	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.V245A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.5825
p.V245A	ACH-000937	Leukemia	CCLE	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.5825
p.V245A	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.5825
p.L237F	SIDM00959	Acute Myeloid Leukemia	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.F241C	ACH-002256	Leukemia	CCLE	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3611
p.F241C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75677	Ret finger protein-like 1	LIG_APCC_ABBAyCdc20_2	244:250	RVGIFLD	APC,CDC20,FZR1	0.5402	More...
O75679	Ret finger protein-like 3	LIG_APCC_ABBAyCdc20_2	244:250	RVGIFLD	APC,CDC20,FZR1	0.5054	More...
Q9HCM9	E3 ubiquitin-protein ligase TRIM39	LIG_APCC_ABBAyCdc20_2	457:463	RVGIFLD	APC,CDC20,FZR1	0.5818	More...
O75678	Ret finger protein-like 2	LIG_APCC_ABBAyCdc20_2	305:311	RVGIFLD	APC,CDC20,FZR1	0.5402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RVGIFLD

Degron related mutations and impact score

Drug responses associated with RFPL3 mutations

All proteins holding degron of RVGIFLD