DegronMD - O75678(RFPL2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R301H	TCGA-28-5208	GBM	TCGA	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.1944
p.R301H	TCGA-28-5208	GBM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2222
p.R301H	TCGA-4R-AA8I	LIHC	TCGA	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.1944
p.R301H	TCGA-4R-AA8I	LIHC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2222
p.V299I	TCGA-50-5072	LUAD	TCGA	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.1389
p.V299I	TCGA-50-5072	LUAD	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.1667
p.R301L	TCGA-77-7142	LUSC	TCGA	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.1944
p.R301L	TCGA-77-7142	LUSC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2222
p.D311E	TCGA-AG-A002	READ	TCGA	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation altering degron motif	0.5647
p.D311E	TCGA-AG-A002	READ	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation altering degron motif	0.5647
p.R301C	TCGA-CV-5970	HNSC	TCGA	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.1944
p.R301C	TCGA-CV-5970	HNSC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2222
p.R301S	TCGA-EE-A2GT	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.1944
p.R301S	TCGA-EE-A2GT	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2222
p.S318F	TCGA-EE-A2MH	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.1389
p.S318F	TCGA-EE-A2MH	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.1389
p.D311N	TCGA-W3-AA1Q	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation altering degron motif	0.6932
p.D311N	TCGA-W3-AA1Q	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation altering degron motif	0.6932
p.L301F	DO228631	GACA	ICGC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.1944
p.L301F	DO228631	GACA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2222
p.R312H	DO13647	GBM	ICGC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.3056
p.R312H	DO13647	GBM	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.3056
p.A316V	DO228589	LICA	ICGC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.1944
p.A316V	DO228589	LICA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.1944
p.T307N	DO26270	LUAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation altering degron motif	0.7055
p.T307N	DO26270	LUAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation altering degron motif	0.7055
p.R312C	DO26444	LUSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.3056
p.R312C	DO26444	LUSC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.3056
p.P310S	DO221121	MALY	ICGC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation altering degron motif	0.6752
p.P310S	DO221121	MALY	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation altering degron motif	0.6752
p.E315G	DO38192	STAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.2222
p.E315G	DO38192	STAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2222
p.V295F	DO52412	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.0556
p.P300H	DO43907	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.1667
p.P300H	DO43907	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.1944
p.N303K	DO43755	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.25
p.N303K	DO43755	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2778
p.G313D	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.2778
p.G313D	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2778
p.G313D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.2778
p.G313D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2778
p.G313D	ACH-000995	Leukemia	CCLE	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.2778
p.G313D	ACH-000995	Leukemia	CCLE	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2778
p.G313D	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VGIFLD	LIG_APCC_ABBA_1	306:311	Mutation rewiring degron network	0.2778
p.G313D	Jurkat	haematopoietic and lymphoid tissue	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	305:311	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFPL2

UniProt ID: O75678

Entrez ID: 10739

Protein name: Ret finger protein-like 2 (RING finger protein 79)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFPL2 in