DegronMD

Uniprot ID: O75678

Source protein: Ret finger protein-like 2

Source gene: RFPL2

Class: LIG_APCC_ABBA_1

Location: 306:311

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6529

ASA_SCORE: 10.9667

COIL: 0.0227

CONS_SCORE: 0.9614

DSS_SCORE: 0.036

HELIX: 0.003

FCONS_SCORE: 1.3657

RIG_SCORE: 0.9364

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R301H	TCGA-28-5208	GBM	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.1944
p.R301H	TCGA-4R-AA8I	LIHC	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.1944
p.V299I	TCGA-50-5072	LUAD	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.1389
p.R301L	TCGA-77-7142	LUSC	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.1944
p.D311E	TCGA-AG-A002	READ	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.5647
p.R301C	TCGA-CV-5970	HNSC	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.1944
p.R301S	TCGA-EE-A2GT	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.1944
p.S318F	TCGA-EE-A2MH	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.1389
p.D311N	TCGA-W3-AA1Q	SKCM	TCGA	VGIFLD	LIG_APCC_ABBA_1	0.6932
p.L301F	DO228631	GACA	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.1944
p.R312H	DO13647	GBM	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.3056
p.A316V	DO228589	LICA	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.1944
p.T307N	DO26270	LUAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.7055
p.R312C	DO26444	LUSC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.3056
p.P310S	DO221121	MALY	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.6752
p.E315G	DO38192	STAD	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.2222
p.P300H	DO43907	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.1667
p.N303K	DO43755	UCEC	ICGC	VGIFLD	LIG_APCC_ABBA_1	0.25
p.G313D	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VGIFLD	LIG_APCC_ABBA_1	0.2778
p.G313D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VGIFLD	LIG_APCC_ABBA_1	0.2778
p.G313D	ACH-000995	Leukemia	CCLE	VGIFLD	LIG_APCC_ABBA_1	0.2778
p.G313D	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VGIFLD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00478	Butyrophilin subfamily 3 member A3	LIG_APCC_ABBA_1	461:466	VGIFLD	APC,CDC20,FZR1	0.5632	More...
O75677	Ret finger protein-like 1	LIG_APCC_ABBA_1	245:250	VGIFLD	APC,CDC20,FZR1	0.6529	More...
O75679	Ret finger protein-like 3	LIG_APCC_ABBA_1	245:250	VGIFLD	APC,CDC20,FZR1	0.5402	More...
Q9HCM9	E3 ubiquitin-protein ligase TRIM39	LIG_APCC_ABBA_1	458:463	VGIFLD	APC,CDC20,FZR1	0.6444	More...
O75678	Ret finger protein-like 2	LIG_APCC_ABBA_1	306:311	VGIFLD	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons