DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VGIFLD
Uniprot ID:
O75677
Source protein:
Ret finger protein-like 1
Source gene:
RFPL1
Class:
LIG_APCC_ABBA_1
Location:
245:250
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6529
ASA_SCORE:
10.7167
COIL:
0.0212
CONS_SCORE:
0.9244
DSS_SCORE:
0.0353
HELIX:
0.0025
FCONS_SCORE:
1.4927
RIG_SCORE:
0.9298
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.F259I
TCGA-49-AARQ
LUAD
TCGA
VGIFLD
LIG_APCC_ABBA_1
0.0833
p.F259I
DO51189
LUAD
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.0833
p.R240C
TCGA-A5-A0G2
UCEC
TCGA
VGIFLD
LIG_APCC_ABBA_1
0.1944
p.R240C
DO41235
UCEC
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.1944
p.R240C
SIDM00334
Endometrial Carcinoma
GDSC
VGIFLD
LIG_APCC_ABBA_1
0.1944
p.R240C
ACH-000879
Endometrial/Uterine Cancer
CCLE
VGIFLD
LIG_APCC_ABBA_1
0.1944
p.R240C
MFE-296
endometrium
COSMIC
VGIFLD
LIG_APCC_ABBA_1
0.1944
p.D239Y
TCGA-D1-A17Q
UCEC
TCGA
VGIFLD
LIG_APCC_ABBA_1
0.1667
p.D239Y
DO41903
UCEC
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.1667
p.M251T
TCGA-DX-AB32
SARC
TCGA
VGIFLD
LIG_APCC_ABBA_1
0.3056
p.M251T
DO220102
SARC
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.3056
p.S257F
TCGA-FW-A3R5
SKCM
TCGA
VGIFLD
LIG_APCC_ABBA_1
0.1389
p.S257F
DO220859
MELA
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.1389
p.S257F
DO37406
SKCM
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.1389
p.D250N
TCGA-W3-AA1Q
SKCM
TCGA
VGIFLD
LIG_APCC_ABBA_1
0.6932
p.D250N
DO219487
SKCM
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.6932
p.M251I
TCGA-WE-A8ZX
SKCM
TCGA
VGIFLD
LIG_APCC_ABBA_1
0.3056
p.M251I
DO51291
SKCM
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.3056
p.V256I
TCGA-XK-AAIW
PRAD
TCGA
VGIFLD
LIG_APCC_ABBA_1
0.1667
p.V256I
DO51407
PRAD
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.1667
p.L249V
DO224876
BRCA
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.5654
p.R240S
DO228948
LICA
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.1944
p.G252V
DO229035
LICA
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.2778
p.S257Y
DO23543
LIRI
ICGC
VGIFLD
LIG_APCC_ABBA_1
0.1389
p.R240H
SIDM01961
Pancreatic Carcinoma
GDSC
VGIFLD
LIG_APCC_ABBA_1
0.1944
p.I247L
SIDM01335
Kidney Carcinoma
GDSC
VGIFLD
LIG_APCC_ABBA_1
0.6063
p.G246E
ACH-001982
Metastasis
CCLE
VGIFLD
LIG_APCC_ABBA_1
0.6087
Drug responses associated with RFPL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VGIFLD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00478
Butyrophilin subfamily 3 member A3
LIG_APCC_ABBA_1
461:466
VGIFLD
APC,CDC20,FZR1
0.5632
More...
O75677
Ret finger protein-like 1
LIG_APCC_ABBA_1
245:250
VGIFLD
APC,CDC20,FZR1
0.6529
More...
O75679
Ret finger protein-like 3
LIG_APCC_ABBA_1
245:250
VGIFLD
APC,CDC20,FZR1
0.5402
More...
Q9HCM9
E3 ubiquitin-protein ligase TRIM39
LIG_APCC_ABBA_1
458:463
VGIFLD
APC,CDC20,FZR1
0.6444
More...
O75678
Ret finger protein-like 2
LIG_APCC_ABBA_1
306:311
VGIFLD
APC,CDC20,FZR1
0.6529
More...