DegronMD

Uniprot ID: O75678

Source protein: Ret finger protein-like 2

Source gene: RFPL2

Class: LIG_APCC_ABBAyCdc20_2

Location: 305:311

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5402

ASA_SCORE: 19.4

COIL: 0.0279

CONS_SCORE: 0.9536

DSS_SCORE: 0.034

HELIX: 0.0026

FCONS_SCORE: 1.3548

RIG_SCORE: 0.9368

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R301H	TCGA-28-5208	GBM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R301H	TCGA-4R-AA8I	LIHC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V299I	TCGA-50-5072	LUAD	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R301L	TCGA-77-7142	LUSC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D311E	TCGA-AG-A002	READ	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.5647
p.R301C	TCGA-CV-5970	HNSC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R301S	TCGA-EE-A2GT	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S318F	TCGA-EE-A2MH	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D311N	TCGA-W3-AA1Q	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.6932
p.L301F	DO228631	GACA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R312H	DO13647	GBM	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A316V	DO228589	LICA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.T307N	DO26270	LUAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7055
p.R312C	DO26444	LUSC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P310S	DO221121	MALY	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.6752
p.E315G	DO38192	STAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V295F	DO52412	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P300H	DO43907	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N303K	DO43755	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G313D	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G313D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G313D	ACH-000995	Leukemia	CCLE	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G313D	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75677	Ret finger protein-like 1	LIG_APCC_ABBAyCdc20_2	244:250	RVGIFLD	APC,CDC20,FZR1	0.5402	More...
O75679	Ret finger protein-like 3	LIG_APCC_ABBAyCdc20_2	244:250	RVGIFLD	APC,CDC20,FZR1	0.5054	More...
Q9HCM9	E3 ubiquitin-protein ligase TRIM39	LIG_APCC_ABBAyCdc20_2	457:463	RVGIFLD	APC,CDC20,FZR1	0.5818	More...
O75678	Ret finger protein-like 2	LIG_APCC_ABBAyCdc20_2	305:311	RVGIFLD	APC,CDC20,FZR1	0.5402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RVGIFLD

Degron related mutations and impact score

Drug responses associated with RFPL2 mutations

All proteins holding degron of RVGIFLD