DegronMD

Uniprot ID: Q9HCM9

Source protein: E3 ubiquitin-protein ligase TRIM39

Source gene: TRIM39

Class: LIG_APCC_ABBAyCdc20_2

Location: 457:463

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5818

ASA_SCORE: 17.1857

COIL: 0.0504

CONS_SCORE: 0.7487

DSS_SCORE: 0.0741

HELIX: 0.0024

FCONS_SCORE: 1.1926

RIG_SCORE: 0.904

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L449F	TCGA-06-1805	GBM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.I451T	TCGA-B5-A3FA	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R457Q	TCGA-CK-4952	COAD	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7329
p.T468A	TCGA-DI-A1BU	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.6389
p.A466V	TCGA-FW-A3TU	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.25
p.R447H	DO233696	GACA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R447H	ARH-77	haematopoietic_and_lymphoid_tissue	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P467S	DO14160	HNSC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P467S	DO26435	LUSC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.W462C	DO24100	LUAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7
p.E459K	DO219165	LUSC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7022
p.R470W	DO51766	STAD	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R470Q	DO42753	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R470L	NCI-H1623	lung	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75677	Ret finger protein-like 1	LIG_APCC_ABBAyCdc20_2	244:250	RVGIFLD	APC,CDC20,FZR1	0.5402	More...
O75679	Ret finger protein-like 3	LIG_APCC_ABBAyCdc20_2	244:250	RVGIFLD	APC,CDC20,FZR1	0.5054	More...
Q9HCM9	E3 ubiquitin-protein ligase TRIM39	LIG_APCC_ABBAyCdc20_2	457:463	RVGIFLD	APC,CDC20,FZR1	0.5818	More...
O75678	Ret finger protein-like 2	LIG_APCC_ABBAyCdc20_2	305:311	RVGIFLD	APC,CDC20,FZR1	0.5402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons