DegronMD

Uniprot ID: O75677

Source protein: Ret finger protein-like 1

Source gene: RFPL1

Class: LIG_APCC_ABBAyCdc20_2

Location: 244:250

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5402

ASA_SCORE: 18.8571

COIL: 0.0264

CONS_SCORE: 0.9161

DSS_SCORE: 0.0338

HELIX: 0.0021

FCONS_SCORE: 1.4762

RIG_SCORE: 0.9295

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R244Q	SIDM00656	Burkitt's Lymphoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R244Q	SIDM01112	Osteosarcoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R244Q	SIDM00879	Breast Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R244Q	SIDM00849	Kidney Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R244Q	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R244Q	SIDM00641	Burkitt's Lymphoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R244Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R244Q	SIDM01409	Bladder Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.7329
p.D250N	TCGA-W3-AA1Q	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D250N	DO219487	SKCM	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.6932
p.G246E	ACH-001982	Metastasis	CCLE	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.6087
p.I247L	SIDM01335	Kidney Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.6063
p.L249V	DO224876	BRCA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.5654
p.M251T	TCGA-DX-AB32	SARC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.M251T	DO220102	SARC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.M251I	TCGA-WE-A8ZX	SKCM	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.M251I	DO51291	SKCM	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G252V	DO229035	LICA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R240C	TCGA-A5-A0G2	UCEC	TCGA	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240C	DO41235	UCEC	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240C	SIDM00334	Endometrial Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240C	ACH-000879	Endometrial/Uterine Cancer	CCLE	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240C	MFE-296	endometrium	COSMIC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240S	DO228948	LICA	ICGC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R240H	SIDM01961	Pancreatic Carcinoma	GDSC	RVGIFLD	LIG_APCC_ABBAyCdc20_2	0.2222

Showing 1 to 25 of 35 entries

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Drug responses associated with RFPL1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of RVGIFLD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCM9	E3 ubiquitin-protein ligase TRIM39	LIG_APCC_ABBAyCdc20_2	457:463	RVGIFLD	APC,CDC20,FZR1	0.5818	More...
O75677	Ret finger protein-like 1	LIG_APCC_ABBAyCdc20_2	244:250	RVGIFLD	APC,CDC20,FZR1	0.5402	More...
O75678	Ret finger protein-like 2	LIG_APCC_ABBAyCdc20_2	305:311	RVGIFLD	APC,CDC20,FZR1	0.5402	More...
O75679	Ret finger protein-like 3	LIG_APCC_ABBAyCdc20_2	244:250	RVGIFLD	APC,CDC20,FZR1	0.5054	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RVGIFLD

Degron related mutations and impact score

Drug responses associated with RFPL1 mutations

All proteins holding degron of RVGIFLD