DegronMD

Uniprot ID: Q9Y242

Source protein: Transcription factor 19

Source gene: TCF19

Class: DEG_APCC_DBOX_1

Location: 35:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5246

ASA_SCORE: 45.4444

COIL: 0.6177

CONS_SCORE: 0.8013

DSS_SCORE: 0.2124

HELIX: 0.1201

FCONS_SCORE: 1.2321

RIG_SCORE: 0.8492

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E49D	TCGA-EJ-5503	PRAD	TCGA	HRADLCDVA	DEG_APCC_DBOX_1	0.1667
p.E49D	DO36359	PRAD	ICGC	HRADLCDVA	DEG_APCC_DBOX_1	0.1667
p.A43S	TCGA-FS-A1Z4	SKCM	TCGA	HRADLCDVA	DEG_APCC_DBOX_1	0.6477
p.A43S	DO37462	SKCM	ICGC	HRADLCDVA	DEG_APCC_DBOX_1	0.6477
p.G34C	DO225361	BRCA	ICGC	HRADLCDVA	DEG_APCC_DBOX_1	0.3056
p.R45W	DO229213	THCA	ICGC	HRADLCDVA	DEG_APCC_DBOX_1	0.2778
p.G26R	SIDM00794	Other Solid Cancers	GDSC	HRADLCDVA	DEG_APCC_DBOX_1	0.0833
p.R32H	ACH-001377	Pancreatic Cancer	CCLE	HRADLCDVA	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y242	Transcription factor 19	DEG_APCC_DBOX_1	35:43	HRADLCDVA	APC,CDC20,FZR1	0.5246	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons