DegronMD

Uniprot ID: O94953

Source protein: Lysine-specific demethylase 4B

Source gene: KDM4B

Class: DEG_APCC_DBOX_1

Location: 41:49

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9303

ASA_SCORE: 56.7222

COIL: 0.446

CONS_SCORE: 0.6165

DSS_SCORE: 0.345

HELIX: 0.2101

FCONS_SCORE: 1.1794

RIG_SCORE: 0.7744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I35K	TCGA-AP-A0LD	UCEC	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	0.1667
p.I35K	DO41578	UCEC	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	0.1667
p.Q58H	TCGA-AX-A2IO	UCEC	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	0.0833
p.Q58H	DO40800	UCEC	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	0.0833
p.P51Q	TCGA-ER-A19H	SKCM	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	0.2778
p.P51Q	DO47299	SKCM	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	0.2778
p.P51L	TCGA-NH-A5IV	COAD	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	0.2778
p.P51L	DO49095	COAD	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	0.2778
p.R42L	TCGA-NJ-A4YI	LUAD	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	0.8428
p.R42L	DO218942	LUAD	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	0.8428
p.I49M	DO231056	LUSC	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	0.6507
p.P51S	DO222843	MELA	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	0.2778
p.V32M	SIDM02050	Colorectal Carcinoma	GDSC	HRAGLAKII	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94953	Lysine-specific demethylase 4B	DEG_APCC_DBOX_1	41:49	HRAGLAKII	APC,CDC20,FZR1	0.9303	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons