DegronMD - O94953(KDM4B)

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.

GO - Biological processes (BP): chromatin remodeling [GO:0006338]; histone H3-K36 demethylation [GO:0070544]; histone H3-K9 demethylation [GO:0033169]

GO - Molecular function (MF): histone demethylase activity [GO:0032452]; histone H3-methyl-lysine-36 demethylase activity [GO:0051864]; histone H3-methyl-lysine-9 demethylase activity [GO:0032454]; histone H3-tri/dimethyl-lysine-9 demethylase activity [GO:0140684]; metal ion binding [GO:0046872]

GO - Cellular component (CC): nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
HRAGLAKII	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Lysine-specific demethylase 4B	41:49	More..
TRSPLSVVK	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Lysine-specific demethylase 4B	620:628	More..
VGTPLAT	DEG_SCF_FBW7_1	FBXW7	Lysine-specific demethylase 4B	1063:1069	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R42L	TCGA-NJ-A4YI	LUAD	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8428
p.R42L	DO218942	LUAD	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8428
p.R621Q	TCGA-BR-7707	STAD	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.7329
p.R621Q	DO38487	STAD	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.7329
p.L624M	TCGA-13-0887	OV	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.711
p.L624M	DO31969	OV	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.711
p.S622P	TCGA-DD-AACD	LIHC	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.6752
p.S622P	DO52199	LIHC	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.6752
p.I49M	DO231056	LUSC	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.6507
p.A1068S	DO229034	LICA	ICGC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation altering degron motif	0.6477
p.P623T	TCGA-BH-A0BP	BRCA	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.5919
p.P623T	DO4056	BRCA	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.5919
p.K628N	DO229025	LICA	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.5806
p.R1062L	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.3056
p.R1062L	ACH-000672	Lung Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.3056
p.P51Q	TCGA-ER-A19H	SKCM	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.P51Q	DO47299	SKCM	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.P51L	TCGA-NH-A5IV	COAD	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.P51L	DO49095	COAD	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.P51S	DO222843	MELA	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM4B

UniProt ID: O94953

Entrez ID: 23030

Protein name: Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM4B in