DegronMD - O94953(KDM4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L624M	TCGA-13-0887	OV	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.711
p.L624M	DO31969	OV	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.711
p.E635K	TCGA-A6-5665	COAD	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1389
p.E635K	DO9756	COAD	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1389
p.R611Q	TCGA-A6-6781	COAD	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.0833
p.I35K	TCGA-AP-A0LD	UCEC	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1667
p.I35K	DO41578	UCEC	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1667
p.R612H	TCGA-AP-A1DK	UCEC	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1111
p.R612H	DO233254	GACA	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1111
p.R612H	DO42033	UCEC	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1111
p.Q58H	TCGA-AX-A2IO	UCEC	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0833
p.Q58H	DO40800	UCEC	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0833
p.P623T	TCGA-BH-A0BP	BRCA	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.5919
p.P623T	DO4056	BRCA	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.5919
p.R621Q	TCGA-BR-7707	STAD	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.7329
p.R621Q	DO38487	STAD	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.7329
p.R1060H	TCGA-CR-7380	HNSC	TCGA	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.R1060H	DO14734	HNSC	ICGC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.R1060H	SIDM00596	Endometrial Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.R1060H	ACH-000961	Endometrial/Uterine Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.R1060H	ACH-001517	Endometrial/Uterine Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.S622P	TCGA-DD-AACD	LIHC	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.6752
p.S622P	DO52199	LIHC	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.6752
p.P51Q	TCGA-ER-A19H	SKCM	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.P51Q	DO47299	SKCM	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.P51L	TCGA-NH-A5IV	COAD	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.P51L	DO49095	COAD	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.R42L	TCGA-NJ-A4YI	LUAD	TCGA	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8428
p.R42L	DO218942	LUAD	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8428
p.K628N	DO229025	LICA	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.5806
p.A1068S	DO229034	LICA	ICGC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation altering degron motif	0.6477
p.A1058S	DO229009	LICA	ICGC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1944
p.I49M	DO231056	LUSC	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.6507
p.R617L	DO231120	LUSC	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.25
p.P51S	DO222843	MELA	ICGC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.V32M	SIDM02050	Colorectal Carcinoma	GDSC	HRAGLAKII	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0833
p.P614L	SIDM00545	Melanoma	GDSC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1667
p.P614L	ACH-000987	Skin Cancer	CCLE	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1667
p.P614L	Mewo	skin	COSMIC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1667
p.R1060C	SIDM00241	Breast Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.R1060C	ACH-002179	Breast Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.25
p.R1062L	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.3056
p.R1062L	ACH-000672	Lung Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.3056
p.A1055V	SIDM01128	Small Cell Lung Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1111
p.D1071V	SIDM00783	Colorectal Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.2778
p.D1071V	ACH-000971	Colon/Colorectal Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.2778
p.G615E	LNCaP-Clone-FGC	prostate	COSMIC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1944
p.T1076M	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VGTPLAT	DEG_SCF_FBW7_1	1063:1069	Mutation rewiring degron network	0.1389
p.P631L	LoVo	large intestine	COSMIC	TRSPLSVVK	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.25

Kaplan plot for KDM4B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM4B

UniProt ID: O94953

Entrez ID: 23030

Protein name: Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM4B in