DegronMD

Uniprot ID: O94953

Source protein: Lysine-specific demethylase 4B

Source gene: KDM4B

Class: DEG_APCC_DBOX_1

Location: 620:628

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9397

ASA_SCORE: 88

COIL: 0.7272

CONS_SCORE: 0.2972

DSS_SCORE: 0.7193

HELIX: 0.0308

FCONS_SCORE: 0.9923

RIG_SCORE: 0.6395

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L624M	TCGA-13-0887	OV	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	0.711
p.L624M	DO31969	OV	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	0.711
p.E635K	TCGA-A6-5665	COAD	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	0.1389
p.E635K	DO9756	COAD	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	0.1389
p.R611Q	TCGA-A6-6781	COAD	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	0.0833
p.R612H	TCGA-AP-A1DK	UCEC	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	0.1111
p.R612H	DO233254	GACA	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	0.1111
p.R612H	DO42033	UCEC	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	0.1111
p.P623T	TCGA-BH-A0BP	BRCA	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	0.5919
p.P623T	DO4056	BRCA	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	0.5919
p.R621Q	TCGA-BR-7707	STAD	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	0.7329
p.R621Q	DO38487	STAD	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	0.7329
p.S622P	TCGA-DD-AACD	LIHC	TCGA	TRSPLSVVK	DEG_APCC_DBOX_1	0.6752
p.S622P	DO52199	LIHC	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	0.6752
p.K628N	DO229025	LICA	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	0.5806
p.R617L	DO231120	LUSC	ICGC	TRSPLSVVK	DEG_APCC_DBOX_1	0.25
p.P614L	SIDM00545	Melanoma	GDSC	TRSPLSVVK	DEG_APCC_DBOX_1	0.1667
p.P614L	ACH-000987	Skin Cancer	CCLE	TRSPLSVVK	DEG_APCC_DBOX_1	0.1667
p.P614L	Mewo	skin	COSMIC	TRSPLSVVK	DEG_APCC_DBOX_1	0.1667
p.G615E	LNCaP-Clone-FGC	prostate	COSMIC	TRSPLSVVK	DEG_APCC_DBOX_1	0.1944
p.P631L	LoVo	large_intestine	COSMIC	TRSPLSVVK	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94953	Lysine-specific demethylase 4B	DEG_APCC_DBOX_1	620:628	TRSPLSVVK	APC,CDC20,FZR1	0.9397	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons