DegronMD

Uniprot ID: O94953

Source protein: Lysine-specific demethylase 4B

Source gene: KDM4B

Class: DEG_SCF_FBW7_1

Location: 1063:1069

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 76.1

COIL: 0.9197

CONS_SCORE: 0.2755

DSS_SCORE: 0.6195

HELIX: 0.0327

FCONS_SCORE: 1.0098

RIG_SCORE: 0.6772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1060H	TCGA-CR-7380	HNSC	TCGA	VGTPLAT	DEG_SCF_FBW7_1	0.25
p.R1060H	DO14734	HNSC	ICGC	VGTPLAT	DEG_SCF_FBW7_1	0.25
p.R1060H	SIDM00596	Endometrial Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	0.25
p.R1060H	ACH-000961	Endometrial/Uterine Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	0.25
p.R1060H	ACH-001517	Endometrial/Uterine Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	0.25
p.A1068S	DO229034	LICA	ICGC	VGTPLAT	DEG_SCF_FBW7_1	0.6477
p.A1058S	DO229009	LICA	ICGC	VGTPLAT	DEG_SCF_FBW7_1	0.1944
p.R1060C	SIDM00241	Breast Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	0.25
p.R1060C	ACH-002179	Breast Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	0.25
p.R1062L	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	0.3056
p.R1062L	ACH-000672	Lung Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	0.3056
p.A1055V	SIDM01128	Small Cell Lung Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	0.1111
p.D1071V	SIDM00783	Colorectal Carcinoma	GDSC	VGTPLAT	DEG_SCF_FBW7_1	0.2778
p.D1071V	ACH-000971	Colon/Colorectal Cancer	CCLE	VGTPLAT	DEG_SCF_FBW7_1	0.2778
p.T1076M	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VGTPLAT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94953	Lysine-specific demethylase 4B	DEG_SCF_FBW7_1	1063:1069	VGTPLAT	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons