DegronMD

Uniprot ID: Q9H0D2

Source protein: Zinc finger protein 541

Source gene: ZNF541

Class: DEG_APCC_DBOX_1

Location: 271:279

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8822

ASA_SCORE: 91.4444

COIL: 0.3938

CONS_SCORE: 0.4598

DSS_SCORE: 0.5084

HELIX: 0.4587

FCONS_SCORE: 1.0906

RIG_SCORE: 0.7634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R272W	TCGA-AX-A2HD	UCEC	TCGA	HRDLLRRIV	DEG_APCC_DBOX_1	0.8634
p.R272W	DO42608	UCEC	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	0.8634
p.R277H	TCGA-D5-6932	COAD	TCGA	HRDLLRRIV	DEG_APCC_DBOX_1	0.7133
p.R277H	DO9378	COAD	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	0.7133
p.R277H	DO222842	COCA	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	0.7133
p.R277H	ACH-001494	Bile Duct Cancer	CCLE	HRDLLRRIV	DEG_APCC_DBOX_1	0.7133
p.P288L	TCGA-QC-A7B5	SARC	TCGA	HRDLLRRIV	DEG_APCC_DBOX_1	0.0833
p.P288L	DO220239	SARC	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	0.0833
p.P288S	TCGA-QC-A7B5	SARC	TCGA	HRDLLRRIV	DEG_APCC_DBOX_1	0.0833
p.P288S	DO220239	SARC	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	0.0833
p.S264Y	DO228224	LICA	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	0.5833
p.R277S	DO229038	LICA	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	0.6316
p.L274V	DO35083	PACA	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	0.5654
p.V283I	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	HRDLLRRIV	DEG_APCC_DBOX_1	0.2222
p.V283I	ACH-000109	Lung Cancer	CCLE	HRDLLRRIV	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0D2	Zinc finger protein 541	DEG_APCC_DBOX_1	271:279	HRDLLRRIV	APC,CDC20,FZR1	0.8822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons