DegronMD - Q9H0D2(ZNF541)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S50T	TCGA-AR-A24Q	BRCA	TCGA	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.1111
p.S50T	DO3524	BRCA	ICGC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.1111
p.R272W	TCGA-AX-A2HD	UCEC	TCGA	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8634
p.R272W	TCGA-AX-A2HD	UCEC	TCGA	LLPHRD	LIG_APCC_ABBA_1	268:273	Mutation altering degron motif	0.7523
p.R272W	DO42608	UCEC	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8634
p.R272W	DO42608	UCEC	ICGC	LLPHRD	LIG_APCC_ABBA_1	268:273	Mutation altering degron motif	0.7523
p.R277H	TCGA-D5-6932	COAD	TCGA	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.7133
p.R277H	DO9378	COAD	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.7133
p.R277H	DO222842	COCA	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.7133
p.R277H	ACH-001494	Bile Duct Cancer	CCLE	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.7133
p.T60M	TCGA-DM-A28A	COAD	TCGA	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation altering degron motif	0.7423
p.T60M	DO7878	COAD	ICGC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation altering degron motif	0.7423
p.P54L	TCGA-L5-A8NV	ESCA	TCGA	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.2222
p.P54L	SIDM00856	Other Solid Cancers	GDSC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.2222
p.P288L	TCGA-QC-A7B5	SARC	TCGA	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.0833
p.P288L	DO220239	SARC	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.0833
p.P288S	TCGA-QC-A7B5	SARC	TCGA	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.0833
p.P288S	DO220239	SARC	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.0833
p.S64F	DO233938	GACA	ICGC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation altering degron motif	0.7982
p.S264Y	DO228224	LICA	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation blocking phosphorylation signal	0.5833
p.S264Y	DO228224	LICA	ICGC	LLPHRD	LIG_APCC_ABBA_1	268:273	Mutation blocking phosphorylation signal	0.6667
p.P61T	DO229032	LICA	ICGC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation altering degron motif	0.7031
p.R277S	DO229038	LICA	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6316
p.P59S	DO222731	MELA	ICGC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation altering degron motif	0.5641
p.L274V	DO35083	PACA	ICGC	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.5654
p.T74S	DO36822	READ	ICGC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.0556
p.L58F	SIDM00623	Other Blood Cancers	GDSC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation altering degron motif	0.6981
p.L58F	Mo-T	haematopoietic and lymphoid tissue	COSMIC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation altering degron motif	0.6981
p.V283I	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.V283I	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	LLPHRD	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.0556
p.V283I	ACH-000109	Lung Cancer	CCLE	HRDLLRRIV	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.V283I	ACH-000109	Lung Cancer	CCLE	LLPHRD	LIG_APCC_ABBA_1	268:273	Mutation rewiring degron network	0.0556
p.D73Y	SIDM00018	Acute Myeloid Leukemia	GDSC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.0833
p.D73Y	ACH-000498	Leukemia	CCLE	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.0833
p.D73Y	KO52	haematopoietic and lymphoid tissue	COSMIC	LPTPDMS	DEG_SCF_FBW7_1	58:64	Mutation rewiring degron network	0.0833

Kaplan plot for ZNF541 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF541

UniProt ID: Q9H0D2

Entrez ID: 84215

Protein name: Zinc finger protein 541

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF541 in