DegronMD

Uniprot ID: Q9H0D2

Source protein: Zinc finger protein 541

Source gene: ZNF541

Class: DEG_SCF_FBW7_1

Location: 58:64

E3 ligase: FBXW7

DEGRON score: 0.9625

ASA_SCORE: 67.8286

COIL: 0.804

CONS_SCORE: 0.4301

DSS_SCORE: 0.6312

HELIX: 0.0974

FCONS_SCORE: 1.0027

RIG_SCORE: 0.6695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S50T	TCGA-AR-A24Q	BRCA	TCGA	LPTPDMS	DEG_SCF_FBW7_1	0.1111
p.S50T	DO3524	BRCA	ICGC	LPTPDMS	DEG_SCF_FBW7_1	0.1111
p.T60M	TCGA-DM-A28A	COAD	TCGA	LPTPDMS	DEG_SCF_FBW7_1	0.7423
p.T60M	DO7878	COAD	ICGC	LPTPDMS	DEG_SCF_FBW7_1	0.7423
p.P54L	TCGA-L5-A8NV	ESCA	TCGA	LPTPDMS	DEG_SCF_FBW7_1	0.2222
p.P54L	SIDM00856	Other Solid Cancers	GDSC	LPTPDMS	DEG_SCF_FBW7_1	0.2222
p.S64F	DO233938	GACA	ICGC	LPTPDMS	DEG_SCF_FBW7_1	0.7982
p.P61T	DO229032	LICA	ICGC	LPTPDMS	DEG_SCF_FBW7_1	0.7031
p.P59S	DO222731	MELA	ICGC	LPTPDMS	DEG_SCF_FBW7_1	0.5641
p.T74S	DO36822	READ	ICGC	LPTPDMS	DEG_SCF_FBW7_1	0.0556
p.L58F	SIDM00623	Other Blood Cancers	GDSC	LPTPDMS	DEG_SCF_FBW7_1	0.6981
p.L58F	Mo-T	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPDMS	DEG_SCF_FBW7_1	0.6981
p.D73Y	SIDM00018	Acute Myeloid Leukemia	GDSC	LPTPDMS	DEG_SCF_FBW7_1	0.0833
p.D73Y	ACH-000498	Leukemia	CCLE	LPTPDMS	DEG_SCF_FBW7_1	0.0833
p.D73Y	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPDMS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0D2	Zinc finger protein 541	DEG_SCF_FBW7_1	58:64	LPTPDMS	FBXW7	0.9625	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons