DegronMD

Uniprot ID: Q9H0D2

Source protein: Zinc finger protein 541

Source gene: ZNF541

Class: LIG_APCC_ABBA_1

Location: 268:273

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9818

ASA_SCORE: 78.5833

COIL: 0.6332

CONS_SCORE: 0.4857

DSS_SCORE: 0.5605

HELIX: 0.2445

FCONS_SCORE: 1.1405

RIG_SCORE: 0.7098

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R272W	TCGA-AX-A2HD	UCEC	TCGA	LLPHRD	LIG_APCC_ABBA_1	0.7523
p.R272W	DO42608	UCEC	ICGC	LLPHRD	LIG_APCC_ABBA_1	0.7523
p.S264Y	DO228224	LICA	ICGC	LLPHRD	LIG_APCC_ABBA_1	0.6667
p.V283I	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	LLPHRD	LIG_APCC_ABBA_1	0.0556
p.V283I	ACH-000109	Lung Cancer	CCLE	LLPHRD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0D2	Zinc finger protein 541	LIG_APCC_ABBA_1	268:273	LLPHRD	APC,CDC20,FZR1	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons