DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
HRDLLVHVE
Uniprot ID:
Q53EZ4
Source protein:
Centrosomal protein of 55 kDa
Source gene:
CEP55
Class:
DEG_APCC_DBOX_1
Location:
452:460
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8338
ASA_SCORE:
51.7111
COIL:
0.0483
CONS_SCORE:
0.7865
DSS_SCORE:
0.2271
HELIX:
0.9521
FCONS_SCORE:
1.2117
RIG_SCORE:
0.8608
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K442N
DO229015
LICA
ICGC
HRDLLVHVE
DEG_APCC_DBOX_1
0.5
p.P448S
ACH-001549
Lung Cancer
CCLE
HRDLLVHVE
DEG_APCC_DBOX_1
0.2222
Drug responses associated with CEP55 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of HRDLLVHVE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q53EZ4
Centrosomal protein of 55 kDa
DEG_APCC_DBOX_1
452:460
HRDLLVHVE
APC,CDC20,FZR1
0.8338
More...