DegronMD - Q53EZ4(CEP55)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K442N	DO229015	LICA	ICGC	HRDLLVHVE	DEG_APCC_DBOX_1	452:460	Mutation blocking ubiquitination signal	0.5
p.P448S	ACH-001549	Lung Cancer	CCLE	HRDLLVHVE	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.2222
p.P448S	ACH-001549	Lung Cancer	CCLE	LLVHVE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.1389

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons