DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LLVHVE
Uniprot ID:
Q53EZ4
Source protein:
Centrosomal protein of 55 kDa
Source gene:
CEP55
Class:
LIG_APCC_ABBA_1
Location:
455:460
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.806
ASA_SCORE:
38.9833
COIL:
0.016
CONS_SCORE:
0.8041
DSS_SCORE:
0.3045
HELIX:
0.9837
FCONS_SCORE:
1.2548
RIG_SCORE:
0.875
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P448S
ACH-001549
Lung Cancer
CCLE
LLVHVE
LIG_APCC_ABBA_1
0.1389
Drug responses associated with CEP55 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LLVHVE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q53EZ4
Centrosomal protein of 55 kDa
LIG_APCC_ABBA_1
455:460
LLVHVE
APC,CDC20,FZR1
0.806
More...